BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Global Gene Expression Analysis of Term Amniotic Fluid Cell-Free Fetal RNA

Dataset: Global Gene Expression Analysis of Term Amniotic Fluid Cell-Free Fetal RNA

The objective of this study was to identify the tissue expression patterns and biological pathways enriched in term amniotic fluid cell-...

Registered by ArrayExpress Uploader
View Dataset

The objective of this study was to identify the tissue expression patterns and biological pathways enriched in term amniotic fluid cell-free fetal RNA by comparing functional genomic analyses of term and second-trimester amniotic fluid supernatants. There were 2,871 significantly differentially regulated genes. In term amniotic fluid, tissue expression analysis showed enrichment of salivary gland, tracheal, and renal transcripts as compared with brain and embryonic neural cells in the second trimester. Functional analysis of genes upregulated at term revealed pathways that were highly specific for postnatal adaptation such as immune function, digestion, respiration, carbohydrate metabolism, and adipogenesis. Inflammation and prostaglandin synthesis, two key processes involved in normal labor, were also activated in term amniotic fluid. This was a prospective whole genome microarray study comparing eight amniotic fluid samples collected from eight women at term who underwent prelabor cesarean delivery and eight second-trimester amniotic fluid samples from routine amniocenteses. A functional annotation tool was used to compare tissue expression patterns in term and second-trimester samples. Pathways analysis software identified physiologic systems, molecular and cellular functions, and upstream regulators that were significantly overrepresented in term amniotic fluid.

Species:
human

Samples:
16

Source:
E-GEOD-46286

Updated:
Dec.12, 2014

Registered:
Jul.12, 2014


Factors: (via ArrayExpress)
Sample STAGE SEX
GSM1128153 second trimester female
GSM1128152 second trimester male
GSM1128152 second trimester male
GSM1128152 second trimester male
GSM1128152 second trimester male
GSM1128153 second trimester female
GSM1128153 second trimester female
GSM1128152 second trimester male
GSM1128145 term female
GSM1128145 term female
GSM1128143 term male
GSM1128143 term male
GSM1128143 term male
GSM1128143 term male
GSM1128145 term female
GSM1128143 term male

Tags

  • brain
  • carbohydrate
  • cell
  • genome
  • gland
  • salivary gland

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2025 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use