Dataset: Transcription profiling of human CD43+ cells isolated from myelodysplastic syndrome patients and normal controls reveals involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.

55 patients with MDS and 11 healthy controls were included in the study. At the time of investigation, 18 patients had RA, 19 RARS and 18...

Registered by ArrayExpress Uploader

View Dataset

55 patients with MDS and 11 healthy controls were included in the study. At the time of investigation, 18 patients had RA, 19 RARS and 18 RAEB. The RAEB group was further subdivided into RAEB1 and RAEB2 for a selected part of the analysis. Bone marrow samples were obtained and CD34+ cells isolated from MDS patients and healthy controls using MACS magnetic cell separation columns. Total RNA was extracted using TRIZOL following the protocol supplied by the manufacturer. RNA was amplified using the Two-Cycle cDNA Synthesis and the Two-Cycle Target Labelling and Control Reagent packages (Affymetrix). Samples were hybridized to GeneChip Human Genome U133 Plus 2.0 arrays. Affymetrix CEL files were pre-processed using Robust MultiChip Analysis (RMA).

Species:: human
Samples:: 66
Source:: E-GEOD-4619
PubMed:: 16527891
Updated:: Dec.12, 2014
Registered:: Sep.21, 2014

Factors: (via ArrayExpress)

Sample	ClinicalInformation	Individual	DiseaseState
GSE4619GSM103346	refractory anemia with excess blasts	MDS1	myelodysplastic syndrome
GSE4619GSM103355	refractory anemia	MDS10	myelodysplastic syndrome
GSE4619GSM103356	refractory anemia with ringed sideroblasts	MDS11	myelodysplastic syndrome
GSE4619GSM103357	refractory anemia	MDS12	myelodysplastic syndrome
GSE4619GSM103358	refractory anemia	MDS13	myelodysplastic syndrome
GSE4619GSM103359	refractory anemia with excess blasts	MDS14	myelodysplastic syndrome
GSE4619GSM103360	refractory anemia with excess blasts	MDS15	myelodysplastic syndrome
GSE4619GSM103361	refractory anemia	MDS16	myelodysplastic syndrome
GSE4619GSM103362	refractory anemia with excess blasts	MDS17	myelodysplastic syndrome
GSE4619GSM103363	refractory anemia	MDS18	myelodysplastic syndrome
GSE4619GSM103367	refractory anemia	MDS19	myelodysplastic syndrome
GSE4619GSM103347	refractory anemia	MDS2	myelodysplastic syndrome
GSE4619GSM103368	refractory anemia with ringed sideroblasts	MDS20	myelodysplastic syndrome
GSE4619GSM103371	refractory anemia with excess blasts	MDS21	myelodysplastic syndrome
GSE4619GSM103372	refractory anemia with ringed sideroblasts	MDS22	myelodysplastic syndrome
GSE4619GSM103373	refractory anemia with excess blasts	MDS23	myelodysplastic syndrome
GSE4619GSM103374	refractory anemia with excess blasts	MDS24	myelodysplastic syndrome
GSE4619GSM103375	refractory anemia with ringed sideroblasts	MDS25	myelodysplastic syndrome
GSE4619GSM103376	refractory anemia with ringed sideroblasts	MDS26	myelodysplastic syndrome
GSE4619GSM103377	refractory anemia with excess blasts	MDS27	myelodysplastic syndrome
GSE4619GSM103378	refractory anemia with excess blasts	MDS28	myelodysplastic syndrome
GSE4619GSM103379	refractory anemia with ringed sideroblasts	MDS29	myelodysplastic syndrome
GSE4619GSM103348	refractory anemia with ringed sideroblasts	MDS3	myelodysplastic syndrome
GSE4619GSM103380	refractory anemia with excess blasts	MDS30	myelodysplastic syndrome
GSE4619GSM103381	refractory anemia	MDS31	myelodysplastic syndrome
GSE4619GSM103382	refractory anemia	MDS32	myelodysplastic syndrome
GSE4619GSM103383	refractory anemia with excess blasts	MDS33	myelodysplastic syndrome
GSE4619GSM103384	refractory anemia	MDS34	myelodysplastic syndrome
GSE4619GSM103385	refractory anemia with ringed sideroblasts	MDS35	myelodysplastic syndrome
GSE4619GSM103386	refractory anemia with excess blasts	MDS36	myelodysplastic syndrome
GSE4619GSM103387	refractory anemia with ringed sideroblasts	MDS37	myelodysplastic syndrome
GSE4619GSM103391	refractory anemia	MDS38	myelodysplastic syndrome
GSE4619GSM103392	refractory anemia with ringed sideroblasts	MDS39	myelodysplastic syndrome
GSE4619GSM103349	refractory anemia	MDS4	myelodysplastic syndrome
GSE4619GSM103393	refractory anemia with ringed sideroblasts	MDS40	myelodysplastic syndrome
GSE4619GSM103394	refractory anemia	MDS41	myelodysplastic syndrome
GSE4619GSM103395	refractory anemia with ringed sideroblasts	MDS42	myelodysplastic syndrome
GSE4619GSM103396	refractory anemia with ringed sideroblasts	MDS43	myelodysplastic syndrome
GSE4619GSM103397	refractory anemia with excess blasts	MDS44	myelodysplastic syndrome
GSE4619GSM103398	refractory anemia with ringed sideroblasts	MDS45	myelodysplastic syndrome
GSE4619GSM103399	refractory anemia	MDS46	myelodysplastic syndrome
GSE4619GSM103400	refractory anemia with excess blasts	MDS47	myelodysplastic syndrome
GSE4619GSM103401	refractory anemia	MDS48	myelodysplastic syndrome
GSE4619GSM103402	refractory anemia with ringed sideroblasts	MDS49	myelodysplastic syndrome
GSE4619GSM103350	refractory anemia with excess blasts	MDS5	myelodysplastic syndrome
GSE4619GSM103403	refractory anemia with ringed sideroblasts	MDS50	myelodysplastic syndrome
GSE4619GSM103404	refractory anemia	MDS51	myelodysplastic syndrome
GSE4619GSM103405	refractory anemia with ringed sideroblasts	MDS52	myelodysplastic syndrome
GSE4619GSM103406	refractory anemia with excess blasts	MDS53	myelodysplastic syndrome
GSE4619GSM103407	refractory anemia with ringed sideroblasts	MDS54	myelodysplastic syndrome
GSE4619GSM103408	refractory anemia	MDS55	myelodysplastic syndrome
GSE4619GSM103351	refractory anemia with ringed sideroblasts	MDS6	myelodysplastic syndrome
GSE4619GSM103352	refractory anemia with excess blasts	MDS7	myelodysplastic syndrome
GSE4619GSM103353	refractory anemia with excess blasts	MDS8	myelodysplastic syndrome
GSE4619GSM103354	refractory anemia	MDS9	myelodysplastic syndrome
GSE4619GSM103343	normal	N1	normal
GSE4619GSM103389	normal	N10	normal
GSE4619GSM103390	normal	N11	normal
GSE4619GSM103344	normal	N2	normal
GSE4619GSM103345	normal	N3	normal
GSE4619GSM103364	normal	N4	normal
GSE4619GSM103365	normal	N5	normal
GSE4619GSM103366	normal	N6	normal
GSE4619GSM103369	normal	N7	normal
GSE4619GSM103370	normal	N8	normal
GSE4619GSM103388	normal	N9	normal