ArrayExpress Uploaderarrayexpress_sid7256IVB1 fl/fl, K18 tg, p53 fl/flovarian tumorIIBB2 fl/fl, K18 tg, p53 m/flovarian tumorIVB2 fl/fl, K18 tg, p53 m/flovarian tumorIVB1 fl/fl, K18 tg, p53 m/flovarian tumorIIAB2 fl/fl, K18 tg, p53 m/flovarian tumorIVB2 fl/fl, K18 tg, p53 m/flovarian tumorIIAB1 fl/fl, K18 tg, p53 m/flovarian tumorIIAB1 fl/fl, K18 tg, p53 m/flovarian tumorIIBB2 fl/fl, K18 tg, p53 m/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumornanK18 tg, p53 fl/flovarian tumornanK18 tg, p53 fl/flovarian tumornot specifiedB1 fl/fl, K18 tg, p53 fl/flovarian tumorIIIBB1 fl/fl, K18 tg, p53 fl/flovarian tumornanB1 fl/fl, K18 tg, p53 fl/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumornanB1 fl/fl, K18 tg, p53 fl/flovarian tumorno dataK18 tg, p53 fl/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumorIBK18 tg, p53 fl/flovarian tumorIBB1 fl/fl, K18 tg, p53 fl/flovarian tumorIIIAB1 fl/fl, K18 tg, p53 fl/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumorIVB1 fl/fl, K18 tg, p53 fl/flovarian tumornot specifiedB1 fl/+, K18, cpovarian tumornot specifiedwild typenormal ovarian epitheliumnot specifiedwild typenormal ovarian epitheliumnot specifiedwild typenormal ovarian epithelium06We have developed mouse models for serous epithelial ovarian cancer (SEOC) based on conditional inactivation of p53 and Rb tumor...22617326/profile/8773/arrayexpressuploader330brca1cancerdiseaseovarian cancersurfaceDec.12, 2014FalseE-GEOD-46169_A-AFFY-45expression-data-from-mouse-seoc-tumorshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46169Expression data from mouse SEOC tumorsNov.12, 2014We have developed mouse models for serous epithelial ovarian cancer (SEOC) based on conditional inactivation of p53 and Rb tumor suppression (RB-TS) in combination with or without Brca1/2 following injection of adenovirus expressing Cre recombinase into the ovarian bursa. These models develop metastatic (Stage IV) disease with key histopathological features resembling human SEOC.To determine whether these mouse tumors resemble human SEOC at the molecular level, we conducted global gene expression analysis on 27 ovarian carcinomas and 3 pooled normal ovarian surface epithelium samples (single epithelial layer isolated from ovarian surface by laser capture). RNA was isolated from flash frozen ovarian tumors or from ovarian surface epithelial cells microdissected from frozen sections using PixCell IIe laser capture microdissection instrument.E-GEOD-46169mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46169/samples/