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Home › Dataset Library › Expression data from human glioma tissues

Dataset: Expression data from human glioma tissues

Gliomas are aggressive lethal solid brain tumors arising from support cells in the central nervous system. Despite intense efforts to...

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Gliomas are aggressive lethal solid brain tumors arising from support cells in the central nervous system. Despite intense efforts to optimize the treatment of gliomas, the outcomes of high grade glioma patients are still frustrating. The causes and progress of gliomas have been investigated extensively; however, the genetic factors involved in the development of this disease remain poorly understood. We used microarrays to detail the global program of gene expression in different grade glioma tissues and try to find out some genes associated with the tumorigenesis of gliomas. Grade I to grade IV glioma tissues were selected in surgical operations for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain gene expression profiles. To that end, we hand-selected several genes that were differentially expressed in different grade glioma tissues and then performed a further study to identify the role of these genes in the process of the development of gliomas.

Species:
human

Samples:
22

Source:
E-GEOD-45921

Updated:
Dec.12, 2014

Registered:
Jul.12, 2014


Factors: (via ArrayExpress)
Sample GRADE GLIOMA TYPE
GSM1119689 I astrocytoma
GSM1119688 II astrocytoma
GSM1119689 I astrocytoma
GSM1119686 III astrocytoma
GSM1119685 IV astrocytoma
GSM1119685 IV astrocytoma
GSM1119685 IV astrocytoma
GSM1119686 III astrocytoma
GSM1119688 II astrocytoma
GSM1119685 IV astrocytoma
GSM1119679 II oligodendroglioma
GSM1119678 II ependymoma
GSM1119678 II ependymoma
GSM1119688 II astrocytoma
GSM1119679 II oligodendroglioma
GSM1119678 II ependymoma
GSM1119679 II oligodendroglioma
GSM1119678 II ependymoma
GSM1119688 II astrocytoma
GSM1119686 III astrocytoma
GSM1119679 II oligodendroglioma
GSM1119679 II oligodendroglioma

Tags

  • brain
  • central
  • disease
  • glioma
  • hand
  • nervous system
  • solid

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