ArrayExpress Uploader0mouselungFVBlungFVBlungFVBlungFVBlungFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin ElungFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin ElungFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin ElungFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin Elung adenocarcinomaFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin Elung adenocarcinomaFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin Elung adenocarcinomaFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin Elung adenocarcinomaFVB transgene human surfactant protein C promoter-driven wild-type human Cyclin E7237arrayexpress_sid6FVB mice were engineered to express wild-type human cyclin E under control of the human surfactant C promoter (CEO mice; Ma et al, PNAS...E-GEOD-45744/profile/8773/arrayexpressuploader212adenocarcinomagenomelungproteinDec.12, 2014Falsewhole-genome-expression-data-from-normal-fvb-mouseE-GEOD-45744_A-AFFY-45Whole-genome expression data from normal FVB mouse lung tissue, transgenic cyclin E overexpressing (CEO) normal mouse lung tissue, and transgenic CEO lung adenocarcinomasNov.12, 2014FVB mice were engineered to express wild-type human cyclin E under control of the human surfactant C promoter (CEO mice; Ma et al, PNAS 2007). These mice develop spontaneous lung tumors, which were shown to be adenocarcinoma by histological analysis. Here we compare whole-genome RNA expression levels between the tumors and normal lung of 4 CEO mice as well as 4 nontransgenic animals. RNA was isolated from the lungs of 4 FVB mice and adjacent normal and tumor tissue from 4 FVB transgenes harboring human surfactant protein C- driven wild-type human cyclin E, all 7-11 months in age. These samples were divided into 3 groups of four, and 12 independent hybridizations were performed for analysis with Affymetrix GeneChip Mouse 430 2.0 arrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45744http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45744/samples/