ArrayExpress Uploader0mouseuntreatedtreated with TGF-beta2treated with SB431542 and TGF-beta2treated with 5Z-7-Oxozeaenol and TGF-beta27219arrayexpress_sid6TGF-beta signaling in neural crest cells is required for normal craniofacial development. This signaling can be transduced via TGF-beta...E-GEOD-45491/profile/8773/arrayexpressuploader14cellcrestmesenchymal cellneural crestDec.12, 2014Falseexpression-profiling-in-palatal-mesenchymal-cellsE-GEOD-45491_A-AFFY-45Expression profiling in palatal mesenchymal cells stimulated with TGF-beta2 in the presence and absence of TGFbRI and Tak1 kinase inhibitorsNov.12, 2014TGF-beta signaling in neural crest cells is required for normal craniofacial development. This signaling can be transduced via TGF-beta type I receptors (TGFbRI) using Smad-dependent or Smad independent signaling pathways. We used microarrays to identify TGF-beta-responsive genes that are dependent either on TGFbRI kinase, Tak1 kinase or both. Primary palatal mesenchymal cell cultures were established. Cultured cells were stimulated with TGF-beta2 in the presence or absence of TGFbRI kinase and Tak1 kinase inhibitors. Unstimulated cells were used as controls. Total RNAs were isolated and hybridized on Affymetrix microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45491http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45491/samples/