{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1105583": {"TREATMENT": "untreated"}}, {"GSM1105584": {"TREATMENT": "treated with TGF-beta2"}}, {"GSM1105585": {"TREATMENT": "treated with SB431542 and TGF-beta2"}}, {"GSM1105586": {"TREATMENT": "treated with 5Z-7-Oxozeaenol and TGF-beta2"}}], "id": 7219, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "TGF-beta signaling in neural crest cells is required for normal craniofacial development. This signaling can be transduced via TGF-beta...", "geo_gse_id": "E-GEOD-45491", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["cell", "crest", "mesenchymal cell", "neural crest"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-profiling-in-palatal-mesenchymal-cells", "geo_id_plat": "E-GEOD-45491_A-AFFY-45", "name": "Expression profiling in palatal mesenchymal cells stimulated with TGF-beta2 in the presence and absence of TGFbRI and Tak1 kinase inhibitors", "created": "Nov.12, 2014", "summary": "TGF-beta signaling in neural crest cells is required for normal craniofacial development. This signaling can be transduced via TGF-beta type I receptors (TGFbRI) using Smad-dependent or Smad independent signaling pathways. We used microarrays to identify TGF-beta-responsive genes that are dependent either on TGFbRI kinase, Tak1 kinase or both. Primary palatal mesenchymal cell cultures were established. Cultured cells were stimulated with TGF-beta2 in the presence or absence of TGFbRI kinase and Tak1 kinase inhibitors. Unstimulated cells were used as controls. Total RNAs were isolated and hybridized on Affymetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45491", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45491/samples/"}