{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 7199, "factors": [{"GSM1096555": {"AGE": "young (2 months old)"}}, {"GSM1096555": {"AGE": "young (2 months old)"}}, {"GSM1096555": {"AGE": "young (2 months old)"}}, {"GSM1096555": {"AGE": "young (2 months old)"}}, {"GSM1096559": {"AGE": "middle aged (10 months old)"}}, {"GSM1096559": {"AGE": "middle aged (10 months old)"}}, {"GSM1096559": {"AGE": "middle aged (10 months old)"}}, {"GSM1096559": {"AGE": "middle aged (10 months old)"}}, {"GSM1096563": {"AGE": "late-middle aged (18 months old)"}}, {"GSM1096563": {"AGE": "late-middle aged (18 months old)"}}, {"GSM1096563": {"AGE": "late-middle aged (18 months old)"}}, {"GSM1096563": {"AGE": "late-middle aged (18 months old)"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However,...", "pubmed_id": 23638090, "geo_gse_id": "E-GEOD-45044", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["disease", "middle", "parkinson's disease", "substantia nigra", "substantia nigra pars compacta", "ventral", "ventral tegmental area"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "age-mediated-transcriptomic-changes-in-adult-mou-2", "geo_id_plat": "E-GEOD-45044_A-AFFY-45", "name": "Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area", "created": "Nov.12, 2014", "summary": "Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However, ventral tegmental area (VTA), a region adjacent to SNpc, is less affected in PD. Until now, molecular mechanisms behind VTA aging have not been fully investigated using high throughput techniques. Here, aging-associated early changes in transcriptome of VTA were investigated comparing late middle-aged (18 months old) to young (2 months old) mice. Three age groups of C57 wild type mice were used in microarray analysis: young (2 months old), middle aged (10 months old), and late-middle aged (18 months old) mice. Four replicates were included in each age group and each replicate was pooled from 5 mice (5 mice/replicate x 4 replicates x 3 age groups). Total RNA was isolated from VTA for hybridization on Affymetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45044", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45044/samples/"}