{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 7196, "factors": [{"GSM1095896": {"GENOTYPE": "CTL"}}, {"GSM1095896": {"GENOTYPE": "CTL"}}, {"GSM1095896": {"GENOTYPE": "CTL"}}, {"GSM1095899": {"GENOTYPE": "IDH1wt"}}, {"GSM1095899": {"GENOTYPE": "IDH1wt"}}, {"GSM1095899": {"GENOTYPE": "IDH1wt"}}, {"GSM1095902": {"GENOTYPE": "IDH1mut"}}, {"GSM1095902": {"GENOTYPE": "IDH1mut"}}, {"GSM1095902": {"GENOTYPE": "IDH1mut"}}], "pop_total": 0, "platform": 6, "summary_wrapped": "Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer,...", "pubmed_id": 23954893, "geo_gse_id": "E-GEOD-45019", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 9, "tags": ["acute myeloid leukemia", "bone", "bone marrow", "cancer", "chondrosarcoma", "glioma", "leukemia", "lymphoma", "melanoma", "myeloid leukemia", "thyroid cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-changes-induced-by-overexpressio-3", "geo_id_plat": "E-GEOD-45019_A-AFFY-45", "name": "Gene expression changes induced by overexpression of IDH1mut in the sorted mouse bone marrow cells", "created": "Nov.12, 2014", "summary": "Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene expression, and thus may promote tumorigenesis. HoxA9 immortalized bone marrow cells from C57BJ/6 mice were transduced with either empty vector or pSF91-IDH1wt-IRES-EGFP, or pSF91-IDH1mut-IRES-GFP and transplanted in irradiated recipient mice. Four weeks after transplantation, GFP+ cells were sorted from mouse bone marrow, from which total RNA was extracted and subjected to microarray analysis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45019", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-45019/samples/"}