BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice

Dataset: Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice

ICR-derived glomerulonephritis (ICGN) mice is a novel inbred strain of mice with a hereditary nephrotic syndrome. Deletion mutation of...

Registered by ArrayExpress Uploader
View Dataset

ICR-derived glomerulonephritis (ICGN) mice is a novel inbred strain of mice with a hereditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice, however, existence of other associative factors has been suggested. To identify additional associative factors and to better understand onset mechanism of nephrotic syndrome in ICGN mice, comprehensive gene expression analysis using DNA microarray was conducted. Immune-related pathways were markedly altered in ICGN mice kidney as compared with ICR mice. Furthermore, gene expression level of complement component 1, s subcomponent (C1s), whose human homologue has been reported to associate with lupus nephritis, was markedly low in ICGN mice kidney. RNA from renal cortex of 4- and 8-week-old ICGN and ICR mice was extracted and processed for hybridization on Affymetrix microarrays (N=3).

Species:
mouse

Samples:
12

Source:
E-GEOD-45005

Updated:
Dec.12, 2014

Registered:
Nov.12, 2014


Factors: (via ArrayExpress)
Sample AGE PHENOTYPE STRAIN OR LINE
GSM1095709 4 weeks nephrotic syndrome ICGN
GSM1095709 4 weeks nephrotic syndrome ICGN
GSM1095709 4 weeks nephrotic syndrome ICGN
GSM1095712 4 weeks normal ICR
GSM1095712 4 weeks normal ICR
GSM1095712 4 weeks normal ICR
GSM1095715 8 weeks nephrotic syndrome ICGN
GSM1095715 8 weeks nephrotic syndrome ICGN
GSM1095715 8 weeks nephrotic syndrome ICGN
GSM1095718 8 weeks normal ICR
GSM1095718 8 weeks normal ICR
GSM1095718 8 weeks normal ICR

Tags

  • cortex
  • glomerulonephritis
  • kidney
  • lupus
  • nephritis
  • nephrotic syndrome
  • syndrome

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2025 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use