ArrayExpress Uploaderarrayexpress_sidhumanBRD755272 hBRD755272 hBRD755272 hBRD75526 hBRD75526 hBRD75526 hDMSOcontrolDMSOcontrolDMSOcontrol251404Three master regulatory transcription factors Pdx1, MafA and Ngn3 have the ability to transdifferentiate pancreatic acinar cells to...E-GEOD-44946/profile/8773/arrayexpressuploader29insulinDec.12, 2014FalseE-GEOD-44946_A-AFFY-44expression-data-by-brd7552-treatment-in-panc-1-celExpression data by BRD7552 treatment in PANC-1 cellsJul.12, 2014Three master regulatory transcription factors Pdx1, MafA and Ngn3 have the ability to transdifferentiate pancreatic acinar cells to insulin-producing beta cells in mice. BRD7552 was identified as a small-molecule inducer that can upregulate the expression of Pdx1 in PANC-1 cells by high-throughput qPCR screening. We used microarrays to illustrate the mechnism of BRD7552 for PDX1 and insulin induction. PANC-1 cells were treated with BRD7552 at 5uM, the mininal concentration for the maximal induction of Pdx1. The RNA was isloated at two time points 6-hour and 72-hour.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44946http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44946/samples/