{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM1094294": {"TREATMENT": "BRD7552", "TIME": "72 h"}}, {"GSM1094294": {"TREATMENT": "BRD7552", "TIME": "72 h"}}, {"GSM1094294": {"TREATMENT": "BRD7552", "TIME": "72 h"}}, {"GSM109429": {"TREATMENT": "BRD7552", "TIME": "6 h"}}, {"GSM109429": {"TREATMENT": "BRD7552", "TIME": "6 h"}}, {"GSM109429": {"TREATMENT": "BRD7552", "TIME": "6 h"}}, {"GSM1094288": {"TREATMENT": "DMSO", "TIME": "control"}}, {"GSM1094288": {"TREATMENT": "DMSO", "TIME": "control"}}, {"GSM1094288": {"TREATMENT": "DMSO", "TIME": "control"}}], "id": 2514, "pop_total": 0, "platform": 4, "summary_wrapped": "Three master regulatory transcription factors Pdx1, MafA and Ngn3 have the ability to transdifferentiate pancreatic acinar cells to...", "geo_gse_id": "E-GEOD-44946", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 9, "tags": ["insulin"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-44946_A-AFFY-44", "slug": "expression-data-by-brd7552-treatment-in-panc-1-cel", "geo_gds_id": "", "name": "Expression data by BRD7552 treatment in PANC-1 cells", "created": "Jul.12, 2014", "summary": "Three master regulatory transcription factors Pdx1, MafA and Ngn3 have the ability to transdifferentiate pancreatic acinar cells to insulin-producing beta cells in mice. BRD7552 was identified as a small-molecule inducer that can upregulate the expression of Pdx1 in PANC-1 cells by high-throughput qPCR screening. We used microarrays to illustrate the mechnism of BRD7552 for PDX1 and insulin induction. PANC-1 cells were treated with BRD7552 at 5uM, the mininal concentration for the maximal induction of Pdx1. The RNA was isloated at two time points 6-hour and 72-hour.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44946", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44946/samples/"}