Dataset: Transcriptomal profiling of C57BL/6 wild type and ER-alpha KO mice fetal mammary gland after fetal exposure to Bisphenol A (BPA) and 17alpha-ethynylestradiol (EE2)
To examine whether the BPA-induced morphological alterations of the fetal mouse mammary glands are a) associated with changes in mRNA...
To examine whether the BPA-induced morphological alterations of the fetal mouse mammary glands are a) associated with changes in mRNA expression reflecting estrogenic actions and/or b) dependent on the estrogen receptor α (ERα), we compared the transcriptomal effects of BPA and the steroidal estrogen ethinylestradiol (EE2) on fetal mammary tissues of wild type and ERα knock-out mice. Mammary glands from fetuses of dams exposed to vehicle, 250 ng BPA/kg BW/d or 10 ng EE2/kg BW/d from embryonic day (E) 8 were harvested at E19. Total RNA was subjected to transcriptomal profiling using Affymetrix mouse genome 430 2.0 microarray.
- Species:
- mouse
- Samples:
- 36
- Source:
- E-GEOD-44387
- Updated:
- Dec.12, 2014
- Registered:
- Nov.12, 2014
| Sample | GENOTYPE | EXPOSURE |
|---|---|---|
| GSM1084156 | wild type | vehicle |
| GSM1084156 | wild type | vehicle |
| GSM1084156 | wild type | vehicle |
| GSM1084159 | wild type | BPA (250 ng/kg), E8-E19 |
| GSM1084159 | wild type | BPA (250 ng/kg), E8-E19 |
| GSM1084159 | wild type | BPA (250 ng/kg), E8-E19 |
| GSM1084162 | wild type | EE2 (10 ng/kg), E8-E19 |
| GSM1084162 | wild type | EE2 (10 ng/kg), E8-E19 |
| GSM1084162 | wild type | EE2 (10 ng/kg), E8-E19 |
| GSM1084165 | ER-alpha knockout null | vehicle |
| GSM1084165 | ER-alpha knockout null | vehicle |
| GSM1084165 | ER-alpha knockout null | vehicle |
| GSM1084168 | ER-alpha knockout null | BPA (250 ng/kg), E8-E19 |
| GSM1084168 | ER-alpha knockout null | BPA (250 ng/kg), E8-E19 |
| GSM1084168 | ER-alpha knockout null | BPA (250 ng/kg), E8-E19 |
| GSM108417 | ER-alpha knockout null | EE2 (10 ng/kg), E8-E19 |
| GSM108417 | ER-alpha knockout null | EE2 (10 ng/kg), E8-E19 |
| GSM108417 | ER-alpha knockout null | EE2 (10 ng/kg), E8-E19 |
| GSM1084156 | wild type | vehicle |
| GSM1084156 | wild type | vehicle |
| GSM1084156 | wild type | vehicle |
| GSM1084159 | wild type | BPA (250 ng/kg), E8-E19 |
| GSM1084159 | wild type | BPA (250 ng/kg), E8-E19 |
| GSM1084159 | wild type | BPA (250 ng/kg), E8-E19 |
| GSM1084162 | wild type | EE2 (10 ng/kg), E8-E19 |
| GSM1084162 | wild type | EE2 (10 ng/kg), E8-E19 |
| GSM1084162 | wild type | EE2 (10 ng/kg), E8-E19 |
| GSM1084165 | ER-alpha knockout null | vehicle |
| GSM1084165 | ER-alpha knockout null | vehicle |
| GSM1084165 | ER-alpha knockout null | vehicle |
| GSM1084168 | ER-alpha knockout null | BPA (250 ng/kg), E8-E19 |
| GSM1084168 | ER-alpha knockout null | BPA (250 ng/kg), E8-E19 |
| GSM1084168 | ER-alpha knockout null | BPA (250 ng/kg), E8-E19 |
| GSM108417 | ER-alpha knockout null | EE2 (10 ng/kg), E8-E19 |
| GSM108417 | ER-alpha knockout null | EE2 (10 ng/kg), E8-E19 |
| GSM108417 | ER-alpha knockout null | EE2 (10 ng/kg), E8-E19 |