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Home › Dataset Library › β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling

Dataset: β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling

To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal...

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To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with β-catenin siRNA and identified β-catenin target genes using DNA microarrays. The list of identified target genes was compared to previously published β-catenin target genes found in the PubMed and the GEO databases. Based on the large number of β-catenin target genes found to be similarly regulated in DLD1, SW480 and LS174T as well as the large overlap with confirmed β-catenin target genes, we conclude that DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study β-catenin regulated genes and signaling pathways 12 arrays (2 cell lines, 2 treatments, 3 biological replicates)

Species:
human

Samples:
12

Source:
E-GEOD-44097

Updated:
Dec.12, 2014

Registered:
Jul.11, 2014


Factors: (via ArrayExpress)
Sample CELL LINE TREATMENT
GSM1078898 SW480 siRNA beta-catenin
GSM1078898 SW480 siRNA beta-catenin
GSM1078898 SW480 siRNA beta-catenin
GSM1078895 SW480 siRNA beta-galactosidase
GSM1078895 SW480 siRNA beta-galactosidase
GSM1078895 SW480 siRNA beta-galactosidase
GSM1078892 DLD1 siRNA beta-catenin
GSM1078892 DLD1 siRNA beta-catenin
GSM1078892 DLD1 siRNA beta-catenin
GSM1078889 DLD1 siRNA beta-galactosidase
GSM1078889 DLD1 siRNA beta-galactosidase
GSM1078889 DLD1 siRNA beta-galactosidase

Tags

  • cancer
  • carcinoma
  • cell
  • colon
  • colon carcinoma
  • colorectal cancer

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