ArrayExpress Uploader0humanSW480siRNA beta-cateninSW480siRNA beta-cateninSW480siRNA beta-cateninSW480siRNA beta-galactosidaseSW480siRNA beta-galactosidaseSW480siRNA beta-galactosidaseDLD1siRNA beta-cateninDLD1siRNA beta-cateninDLD1siRNA beta-cateninDLD1siRNA beta-galactosidaseDLD1siRNA beta-galactosidaseDLD1siRNA beta-galactosidase2173arrayexpress_sid4To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal...E-GEOD-44097/profile/8773/arrayexpressuploader212cancercarcinomacellcoloncolon carcinomacolorectal cancerDec.12, 2014Falsecatenin-target-genes-in-colorectal-carcinoma-cellE-GEOD-44097_A-AFFY-44β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signalingJul.11, 2014To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with β-catenin siRNA and identified β-catenin target genes using DNA microarrays. The list of identified target genes was compared to previously published β-catenin target genes found in the PubMed and the GEO databases. Based on the large number of β-catenin target genes found to be similarly regulated in DLD1, SW480 and LS174T as well as the large overlap with confirmed β-catenin target genes, we conclude that DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study β-catenin regulated genes and signaling pathways 12 arrays (2 cell lines, 2 treatments, 3 biological replicates)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44097http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44097/samples/