{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1078898": {"CELL LINE": "SW480", "TREATMENT": "siRNA beta-catenin"}}, {"GSM1078898": {"CELL LINE": "SW480", "TREATMENT": "siRNA beta-catenin"}}, {"GSM1078898": {"CELL LINE": "SW480", "TREATMENT": "siRNA beta-catenin"}}, {"GSM1078895": {"CELL LINE": "SW480", "TREATMENT": "siRNA beta-galactosidase"}}, {"GSM1078895": {"CELL LINE": "SW480", "TREATMENT": "siRNA beta-galactosidase"}}, {"GSM1078895": {"CELL LINE": "SW480", "TREATMENT": "siRNA beta-galactosidase"}}, {"GSM1078892": {"CELL LINE": "DLD1", "TREATMENT": "siRNA beta-catenin"}}, {"GSM1078892": {"CELL LINE": "DLD1", "TREATMENT": "siRNA beta-catenin"}}, {"GSM1078892": {"CELL LINE": "DLD1", "TREATMENT": "siRNA beta-catenin"}}, {"GSM1078889": {"CELL LINE": "DLD1", "TREATMENT": "siRNA beta-galactosidase"}}, {"GSM1078889": {"CELL LINE": "DLD1", "TREATMENT": "siRNA beta-galactosidase"}}, {"GSM1078889": {"CELL LINE": "DLD1", "TREATMENT": "siRNA beta-galactosidase"}}], "id": 2173, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal...", "geo_gse_id": "E-GEOD-44097", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 12, "tags": ["cancer", "carcinoma", "cell", "colon", "colon carcinoma", "colorectal cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "catenin-target-genes-in-colorectal-carcinoma-cell", "geo_id_plat": "E-GEOD-44097_A-AFFY-44", "name": "\u03b2-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/\u03b2-catenin signaling", "created": "Jul.11, 2014", "summary": "To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with \u03b2-catenin siRNA and identified \u03b2-catenin target genes using DNA microarrays. The list of identified target genes was compared to previously published \u03b2-catenin target genes found in the PubMed and the GEO databases. Based on the large number of \u03b2-catenin target genes found to be similarly regulated in DLD1, SW480 and LS174T as well as the large overlap with confirmed \u03b2-catenin target genes, we conclude that DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study \u03b2-catenin regulated genes and signaling pathways 12 arrays (2 cell lines, 2 treatments, 3 biological replicates)", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44097", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44097/samples/"}