ArrayExpress Uploader07161Sh2b3 wild type ΔE-NOTCH1Sh2b3 wild type ΔE-NOTCH1Sh2b3 wild type ΔE-NOTCH1Sh2b3-/- ΔE-NOTCH1Sh2b3-/- ΔE-NOTCH1Sh2b3-/- ΔE-NOTCH1arrayexpress_sid6To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in...23908464E-GEOD-44025/profile/8773/arrayexpressuploader16bonebone marrowleukemianotchDec.12, 2014Falseexpression-data-from-sh2b3-knock-out-notch1-induceE-GEOD-44025_A-AFFY-45Expression data from Sh2b3 Knock-out NOTCH1-induced leukemiasNov.12, 2014To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full leukemia transformation 5-10 weeks later. We performed microarray gene expression analysis of Sh2b3 wild type and Sh2b3–/– NOTCH1 induced leukemiashttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44025mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44025/samples/