{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 7161, "factors": [{"GSM1076976": {"GENOTYPE": "Sh2b3 wild type \u0394E-NOTCH1"}}, {"GSM1076976": {"GENOTYPE": "Sh2b3 wild type \u0394E-NOTCH1"}}, {"GSM1076976": {"GENOTYPE": "Sh2b3 wild type \u0394E-NOTCH1"}}, {"GSM1076979": {"GENOTYPE": "Sh2b3-/- \u0394E-NOTCH1"}}, {"GSM1076979": {"GENOTYPE": "Sh2b3-/- \u0394E-NOTCH1"}}, {"GSM1076979": {"GENOTYPE": "Sh2b3-/- \u0394E-NOTCH1"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in...", "pubmed_id": 23908464, "geo_gse_id": "E-GEOD-44025", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["bone", "bone marrow", "leukemia", "notch"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-sh2b3-knock-out-notch1-induce", "geo_id_plat": "E-GEOD-44025_A-AFFY-45", "name": "Expression data from Sh2b3 Knock-out NOTCH1-induced leukemias", "created": "Nov.12, 2014", "summary": "To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full leukemia transformation 5-10 weeks later. We performed microarray gene expression analysis of Sh2b3 wild type and Sh2b3\u2013/\u2013 NOTCH1 induced leukemias", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44025", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-44025/samples/"}