ArrayExpress Uploader0humanTNF+PA for 24hrTNF+PA for 24hrpalmitic acid (PA, 500 uM) for 24hpalmitic acid (PA, 500 uM) for 24hTNF-alpha (10 ng/ml) for 24hrTNF-alpha (10 ng/ml) for 24hrnone (Control)none (Control)2137arrayexpress_sid4Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in...E-GEOD-43685/profile/8773/arrayexpressuploader18obesitypalmitic acidplacentaDec.12, 2014Falseearly-growth-response-protein-1-coordinates-lipotoE-GEOD-43685_A-AFFY-44Early growth response protein-1 coordinates lipotoxicity-associated placental inflammation: Role in Maternal ObesityJul.11, 2014Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h. Microarray analysis revealed that placental cytotrophoblasts increased expression of genes related to inflammation, stress response and immediate-early factors in response to plamitic acid, TNF-alpha or a combination of both. Our results suggest that fatty acids and inflammatory cytokines induce inflammation in placental cells via activation of JNK-Egr-1 signaling. global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 hhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43685http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43685/samples/