{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1068195": {"TREATED WITH": "TNF+PA for 24hr"}}, {"GSM1068195": {"TREATED WITH": "TNF+PA for 24hr"}}, {"GSM1068193": {"TREATED WITH": "palmitic acid (PA, 500 uM) for 24h"}}, {"GSM1068193": {"TREATED WITH": "palmitic acid (PA, 500 uM) for 24h"}}, {"GSM106819": {"TREATED WITH": "TNF-alpha (10 ng/ml) for 24hr"}}, {"GSM106819": {"TREATED WITH": "TNF-alpha (10 ng/ml) for 24hr"}}, {"GSM1068189": {"TREATED WITH": "none (Control)"}}, {"GSM1068189": {"TREATED WITH": "none (Control)"}}], "id": 2137, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in...", "geo_gse_id": "E-GEOD-43685", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["obesity", "palmitic acid", "placenta"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "early-growth-response-protein-1-coordinates-lipoto", "geo_id_plat": "E-GEOD-43685_A-AFFY-44", "name": "Early growth response protein-1 coordinates lipotoxicity-associated placental inflammation: Role in Maternal Obesity", "created": "Jul.11, 2014", "summary": "Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h. Microarray analysis revealed that placental cytotrophoblasts increased expression of genes related to inflammation, stress response and immediate-early factors in response to plamitic acid, TNF-alpha or a combination of both. Our results suggest that fatty acids and inflammatory cytokines induce inflammation in placental cells via activation of JNK-Egr-1 signaling. global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43685", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43685/samples/"}