{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM105735": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult normal glandular stomach", "GENOTYPE": "wild type"}}, {"GSM105735": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult normal glandular stomach", "GENOTYPE": "wild type"}}, {"GSM105735": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult normal glandular stomach", "GENOTYPE": "wild type"}}, {"GSM1057354": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic"}}, {"GSM1057354": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic"}}, {"GSM1057354": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic"}}, {"GSM1057357": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic; TNF-alpha knockout"}}, {"GSM1057357": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic; TNF-alpha knockout"}}, {"GSM1057357": {"STRAIN OR LINE": "C57BL/6", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic; TNF-alpha knockout"}}, {"GSM1057360": {"STRAIN OR LINE": "BALB/c", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic"}}, {"GSM1057360": {"STRAIN OR LINE": "BALB/c", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic"}}, {"GSM1057360": {"STRAIN OR LINE": "BALB/c", "ORGANISM PART": "adult gastric tumor in glandular stomach", "GENOTYPE": "Wnt1, Ptgs2, Ptges transgenic"}}], "id": 7120, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Gan mice express Wnt1, Ptgs2, and Ptges, which develop inflammation-associated gastric tumors (Oshima et al, Gastroenterology 131: 1086,...", "geo_gse_id": "E-GEOD-43145", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 12, "tags": ["stomach", "wt1"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-43145_A-AFFY-45", "slug": "expression-data-of-mouse-gastric-tumors-tnf-ko-gan", "geo_gds_id": "", "name": "Expression data of mouse gastric tumors (TNF KO-Gan and BALB/c-Gan mice )", "created": "Nov.12, 2014", "summary": "Gan mice express Wnt1, Ptgs2, and Ptges, which develop inflammation-associated gastric tumors (Oshima et al, Gastroenterology 131: 1086, 2006).  We examined the role of TNF-alpha in tumorigenesis by construction of TNF-/- Gan mice.  We also examined genetic background difference in tumor phenotype by changing Gan mouse background from C57BL/6(B6) to BALB/c. Microarray analyses were performed to examine changes of expression profiles in tumors by TNF gene disruption or by changing genetic background. Total RNA was prepared from B6 Gan mice (n=3: Gan1-Gan3), B6-Gan TNF-/- mice (n=3: Gan(TNF KO)1-Gan(TNF KO)3), BALB-Gan mice (n=3: Gan(BALB/c)1-Gan(BALB/c)3), and wid-type normal glandular stomach (n=3: WT1-WT3).  We used Affymetrix microarrays for hybridization, and examined expression profiles.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43145", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43145/samples/"}