ArrayExpress Uploader07114arrayexpress_sid6The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of...23361907E-GEOD-43067/profile/8773/arrayexpressuploader03bonebone marrowchromosomeleukemiaDec.12, 2014Falseexpression-data-from-mll-af6-positive-leukemia-celE-GEOD-43067_A-AFFY-45Expression data from MLL-AF6 positive leukemia cellsNov.12, 2014The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation system. Leukemic bone marrow cells from a sacrificed moribund mouse were thawed and RNA was extracted using TRIZOL (Invitrogen) and purified further using the RNAeasy kit (Qiagen) under standard conditions and and hybridized onto Affymetrix arrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43067mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-43067/samples/