{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1050378": {"SAMPLE TYPE": "atherosclerotic aortas from APOE-deficient mice", "TREATMENT": "untreated", "GENOTYPE": "APOE-deficient"}}, {"GSM1050378": {"SAMPLE TYPE": "atherosclerotic aortas from APOE-deficient mice", "TREATMENT": "untreated", "GENOTYPE": "APOE-deficient"}}, {"GSM1050380": {"SAMPLE TYPE": "aortas from vitamin E-treated APOE-deficient mice", "TREATMENT": "vitamin E", "GENOTYPE": "APOE-deficient"}}, {"GSM1050380": {"SAMPLE TYPE": "aortas from vitamin E-treated APOE-deficient mice", "TREATMENT": "vitamin E", "GENOTYPE": "APOE-deficient"}}, {"GSM1050382": {"SAMPLE TYPE": "aortas from non-transgenic C57BL/6J mice", "TREATMENT": "untreated", "GENOTYPE": "wild type"}}, {"GSM1050382": {"SAMPLE TYPE": "aortas from non-transgenic C57BL/6J mice", "TREATMENT": "untreated", "GENOTYPE": "wild type"}}], "id": 7101, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Hypercholesterolemic APOE-deficient mice are a widely used experimental model of atherosclerosis and increased generation of reactive...", "geo_gse_id": "E-GEOD-42813", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 6, "tags": ["atherosclerosis", "genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "microarray-gene-expression-profiling-of-aortic-gen", "geo_id_plat": "E-GEOD-42813_A-AFFY-45", "name": "Microarray gene expression profiling of aortic genes of APOE-deficient mice receiving atherosclerosis treatment with the antioxidant vitamin E", "created": "Nov.12, 2014", "summary": "Hypercholesterolemic APOE-deficient mice are a widely used experimental model of atherosclerosis and increased generation of reactive oxygen species (ROS) is a prominent feature of atherosclerosis development. To study the impact of ROS on atherogenesis, we treated APOE-deficient mice for 7 months with the antioxidant vitamin E (2000 IU/kg diet) and performed whole genome microarray gene expression profiling of aortic genes. Microarray gene expression profiling was performed of whole aortas isolated from vitamin E-treated APOE-deficient relative to untreated APOE-deficient mice with overt atherosclerosis, and nontransgenic B6 control mice. Microarray gene expression profiling revealed that vitamin E treatment prevented atherosclerosis-related gene expression changes of the aortic intima and media. Microarray gene expression profiling was performed of whole aortas isolated from APOE-deficient mice with atherosclerosis relative to vitamin E-treated APOE-deficient mice, and nontransgenic B6 control mice. Three study groups were analyzed, i.e. 8 months-old untreated APOE-deficient mice with overt atherosclerosis, age-matched APOE-deficient mice treated for 7 months with the antioxidant vitamin E  (2000 IU/kd diet), and nontransgenic B6 control (C57BL/6J) mice. Two biological replicates were made of each group, and total RNA of three aortas was pooled for one gene chip. The study complements microarray study GSE19286.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42813", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42813/samples/"}