ArrayExpress Uploaderarrayexpress_sidmouseno observed hypertrophyA1no observed hypertrophyA1no observed hypertrophyA1no observed hypertrophyA2no observed hypertrophyA2no observed hypertrophyA2no observed hypertrophyA3no observed hypertrophyA3no observed hypertrophyA3myotube hypertrophy observedA4myotube hypertrophy observedA4myotube hypertrophy observedA4no observed hypertrophyGFP controlno observed hypertrophyGFP controlno observed hypertrophyGFP control708606An alternative promoter of the PGC-1 alpha gene gives arrise to 3 new isofroms of the PGC-1 alpha gene refered to as PGC-1a2 (A2), PGC-...E-GEOD-42473/profile/8773/arrayexpressuploader215proteinproximalDec.12, 2014FalseE-GEOD-42473_A-AFFY-45pgc-1-alpha-isoforms-and-muscle-hypertrophyPGC-1 alpha isoforms and muscle hypertrophyNov.12, 2014An alternative promoter of the PGC-1 alpha gene gives arrise to 3 new isofroms of the PGC-1 alpha gene refered to as PGC-1a2 (A2), PGC-1a3 (A3) and PGC-1a4 (A4). The proximal PGC-1 alpha promotor transcribes the canonical PGC-1 alpha which is refered to as PGC-1a1 (A1).G1/G2/G3 samples refer to the Green fluorescent protein (GFP) control samples used in this experiment. Forced expression of specifically PGC-1a4 isoform results in muslce hypertrophy associated with increased IGF-1 signaling and repression of myostatin signaling. Adnoviral over expression assays were performed on primary myoblasts from C57BL/6 mice for each of the PGC-1 alpha isoforms originating from the proximal or alternative promotor.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42473http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42473/samples/