{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM104877": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A1"}}, {"GSM104877": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A1"}}, {"GSM104877": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A1"}}, {"GSM1048774": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A2"}}, {"GSM1048774": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A2"}}, {"GSM1048774": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A2"}}, {"GSM1048777": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A3"}}, {"GSM1048777": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A3"}}, {"GSM1048777": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "A3"}}, {"GSM1048780": {"MUSCLE HYPERTROPHY": "myotube hypertrophy observed", "PGC-1 ALPHA ISOFORM EXPRESSION": "A4"}}, {"GSM1048780": {"MUSCLE HYPERTROPHY": "myotube hypertrophy observed", "PGC-1 ALPHA ISOFORM EXPRESSION": "A4"}}, {"GSM1048780": {"MUSCLE HYPERTROPHY": "myotube hypertrophy observed", "PGC-1 ALPHA ISOFORM EXPRESSION": "A4"}}, {"GSM1048783": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "GFP control"}}, {"GSM1048783": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "GFP control"}}, {"GSM1048783": {"MUSCLE HYPERTROPHY": "no observed hypertrophy", "PGC-1 ALPHA ISOFORM EXPRESSION": "GFP control"}}], "id": 7086, "pop_total": 0, "platform": 6, "summary_wrapped": "An alternative promoter of the PGC-1 alpha gene gives arrise to 3 new isofroms of the PGC-1 alpha gene refered to as PGC-1a2 (A2), PGC-...", "geo_gse_id": "E-GEOD-42473", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 15, "tags": ["protein", "proximal"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-42473_A-AFFY-45", "slug": "pgc-1-alpha-isoforms-and-muscle-hypertrophy", "geo_gds_id": "", "name": "PGC-1 alpha isoforms and muscle hypertrophy", "created": "Nov.12, 2014", "summary": "An alternative promoter of the PGC-1 alpha gene gives arrise to 3 new isofroms of the PGC-1 alpha gene refered to as PGC-1a2 (A2), PGC-1a3 (A3) and PGC-1a4 (A4). The proximal PGC-1 alpha promotor transcribes the canonical PGC-1 alpha which is refered to as PGC-1a1 (A1).G1/G2/G3 samples refer to the Green fluorescent protein (GFP) control samples used in this experiment. Forced expression of specifically PGC-1a4 isoform results in muslce hypertrophy associated with increased IGF-1 signaling and repression of myostatin signaling. Adnoviral over expression assays were performed on primary myoblasts from C57BL/6 mice for each of the PGC-1 alpha isoforms originating from the proximal or alternative promotor.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42473", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42473/samples/"}