ArrayExpress Uploader0human3single sorted initial leukemia2single sorted initial leukemia1single sorted initial leukemia4single sorted lymphoblasts in complete continuous remission3single sorted lymphoblasts in complete continuous remission2single sorted lymphoblasts in complete continuous remission1single sorted lymphoblasts in complete continuous remission4Initial, untreated leukemia3Initial, untreated leukemia2Initial, untreated leukemia1Initial, untreated leukemia1215arrayexpress_sid3The objective of this study was the assessment of transcriptional dysregulation in particular with regard to B-cell differentiation...E-GEOD-42221/profile/8773/arrayexpressuploader211cellleukemiaDec.12, 2014Falsecomparative-intraindividual-transcriptome-analysisE-GEOD-42221_A-AFFY-33Comparative intraindividual transcriptome analysis of B-precursor ALL of childhoodJun.18, 2014The objective of this study was the assessment of transcriptional dysregulation in particular with regard to B-cell differentiation factors. Most studies focus on cross-section analyses of various leukemia subtypes to identify differentially regulated genes lacking suitable reference models. Here we applied comparative intraindividual transcriptome analysis of B-precursor ALL of childhood, which introduces a side-by-side analysis of leukemic cells and matched normal lymphoblasts from the same individual in complete continuous remission after the end of re-induction therapy. This approach reduces noise by eliminating interindividual variability. Comparative matched pair analysis of (single sorted) initial leukemia and single sorted lymphoblasts isolated from the same individual, n=4 pairs, reference samples are the single sorted normal lymphoblasts. Please note that there are sorted samples form only three of the patients. Due to experimental circumstances, a "sorted" sample from the last patient was not included.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42221http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42221/samples/