ArrayExpress Uploader0humannot specifiedSSK41splenic marginal zone lymphoma cellsnot specifiedSSK41splenic marginal zone lymphoma cellsnot specifiedVL51splenic marginal zone lymphoma cellsnot specifiedVL51splenic marginal zone lymphoma cellsnot specifiedKARPAS-1718splenic marginal zone lymphoma cellsnot specifiedKARPAS-1718splenic marginal zone lymphoma cellsactivated B-cell likeOCI-Ly3diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedOCI-Ly1diffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeOCI-Ly10diffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeU2932diffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeHBL1diffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeHLY1diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedToledodiffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeSUDHL7diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedPFEIFFERdiffuse large B-cell lymphoma (DLBCL) cellsnot specifiedOCI-Ly7diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeOCI-Ly4diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedFARAGEdiffuse large B-cell lymphoma (DLBCL) cellsnot specifiedNUDHL1diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likePR1diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedGRANTA-452diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeDOHH2diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedOCI-Ly19diffuse large B-cell lymphoma (DLBCL) cellsnot specified380diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeSC1diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedROS50diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeSUDHL4diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeDBdiffuse large B-cell lymphoma (DLBCL) cellsnot specifiedNUDUL1diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedOCI-Ly8diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedKARPAS-231diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeSUDHL5diffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeSUDHL8diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedRCK8diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeHtdiffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeKARPAS-422diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeSUDHL10diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedSUDHL6diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeSUDHL16diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedVALdiffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeWSU-DLCL2diffuse large B-cell lymphoma (DLBCL) cellsnot specifiedWSU-NHLdiffuse large B-cell lymphoma (DLBCL) cellsnot specifiedOZdiffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeRIVAdiffuse large B-cell lymphoma (DLBCL) cellsactivated B-cell likeMD901diffuse large B-cell lymphoma (DLBCL) cellsgerminal center B-cell likeRLdiffuse large B-cell lymphoma (DLBCL) cells2688arrayexpress_sid4The multifunctional protein lipopolysaccharide-induced TNFalpha factor (LITAF) induces the secretion of inflammatory cytokines in...E-GEOD-42203/profile/8773/arrayexpressuploader346b-cell lymphomacellchromatindiffuse large b-cell lymphomagenomelipopolysaccharidelymphomamarginal zone lymphomaproteinsplenic marginal zone lymphomaDec.12, 2014Falseglobal-expression-analysis-of-dlbcl-and-smzl-cellE-GEOD-42203_A-AFFY-44Global expression analysis of DLBCL and SMZL cell linesJul.12, 2014The multifunctional protein lipopolysaccharide-induced TNFalpha factor (LITAF) induces the secretion of inflammatory cytokines in monocytes and regulates protein degradation in neural cells. In B-cell lymphomas, LITAF is frequently inactivated by epigenetic mechanisms, but beyond these data little is known about its regulation and function. Immunohistochemical and gene expression profiling analyses of normal and malignant B-cells revealed that LITAF and BCL6 exhibited opposite expression patterns. Accordingly, chromatin immunoprecipitation and luciferase experiments showed that LITAF is transcriptionally repressed by BCL6 in germinal center (GC) lymphocytes and in B-cell lymphoma cells. Gain- and-loss-of-function assays demonstrated that LITAF does not exert any of its previous roles. Conversely, LITAF co-localized with autophagosomes in B-cells whereby activated autophagic responses, which were abrogated upon LITAF silencing. Therefore, BCL6-mediated transcriptional repression of LITAF may contribute to an appropriate GC reaction by suppressing autophagy in GC lymphocytes, whereas constitutive repression of autophagic responses may promote B-cell lymphoma development. 40 diffuse large B-cell lymphoma (DLBCL) and 3 splenic marginal zone lymphoma (SMZL) untreated cell lines were analyzed for global gene expression with the GeneChip® Human Genome U133 Plus 2.0 Array (Affymetrix). SMZL cell lines were hybridized in duplicate, resulting in a total of 46 microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42203http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-42203/samples/