Dataset: Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease

Expression data were generated on 136 subjects from the COPDGene® study using Affymetrix microarrays. Multiple linear regression with...

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Expression data were generated on 136 subjects from the COPDGene® study using Affymetrix microarrays. Multiple linear regression with adjustment for covariates (gender, age, body mass index, family history, smoking status, pack years) was used to identify candidate genes and Ingenuity Pathway Analysis was used to identify candidate pathways. Candidate genes identified included those that play a role in the immune system, inflammatory responses, and sphingolipid metabolism. Many of our final candidate genes also show an association with related disease phenotypes such as emphysema, gas trapping, and 6-minute walk distance. 42 control subjects and 94 subjects with varying severity of COPD had PBMC gene expression profiles generated. All subjects are non-hispanic white, current or former smokers.

Species:: human
Samples:: 136
Source:: E-GEOD-42057
PubMed:: 23590301
Updated:: Dec.12, 2014
Registered:: Jul.12, 2014

Factors: (via ArrayExpress)

Sample	DISTWALKED	BMI	SEX	ATS_PACKYEARS	FINALGOLD	FEV1PP_UTAH	PARENTALCOPD	FEV1_FVC_UTAH	SMOKCIGNOW	AGE_ENROLL	PCTEMPH_SLICER	PCTGASTRAP_SLICER
GSM1031684	0	27.19	1	78	3	36	0	0.42	0	59.6	NA	NA
GSM1031683	1480	27.29	1	24	3	45	0	0.52	0	68	NA	NA
GSM1031682	0	32.09	1	54	0	80	0	0.73	0	59.9	4.49285	24.3711
GSM103168	1810	27.74	1	100	0	84	0	0.73	0	73.3	0.254802	4.98563
GSM1031680	2190	23.68	1	13	0	107	0	0.75	0	65.6	0.421431	1.1664
GSM1031679	1390	27.5	1	14	2	59	0	0.58	0	78.4	4.9119	30.4991
GSM1031678	680	25.94	1	42	4	14	2	0.44	0	61.5	28.7679	77.5963
GSM1031677	1580	25.89	1	27	1	84	0	0.56	0	79.5	17.002	45.4754
GSM1031676	1300	28.93	1	35	3	45	0	0.46	0	62.9	12.3802	47.2773
GSM1031675	1295	30.34	1	75	3	40	0	0.45	0	62.1	24.4507	52.6787
GSM1031674	950	27.33	0	75.6	2	61	0	0.61	1	52.8	0.181475	4.36434
GSM1031673	2000	28.99	1	90	0	119	0	0.76	0	68.9	1.40098	12.9531
GSM1031672	1650	25	0	51.5	-1	74	0	0.74	1	71.2	NA	NA
GSM103167	1550	24.53	0	13.2	-1	79	0	0.74	0	62.8	0.879373	2.91004
GSM1031670	1460	26.68	1	38.7	2	73	2	0.58	1	53.7	3.73906	7.59503
GSM1031669	825	19.9	0	48	4	22	0	0.28	0	71.8	27.0988	68.7283
GSM1031668	1660	29.02	0	20.8	0	81	2	0.81	1	45.8	0.809542	5.2268
GSM1031667	1800	33.46	1	76	0	104	0	0.83	0	57.3	2.28158	8.76129
GSM1031666	0	43.32	0	53.5	3	41	0	0.61	1	67.5	0.971299	20.2854
GSM1031665	1028	25.01	0	30	4	27	0	0.36	0	55.5	19.8811	55.7611
GSM1031664	1000	32.12	1	67.4	3	45	2	0.46	1	59.9	NA	NA
GSM1031663	1700	32.52	1	69.5	0	100	2	0.71	1	61.3	0.710645	4.75145
GSM1031662	0	22.39	1	39	4	14	0	0.24	0	67.9	34.1094	66.3951
GSM103166	1460	33.28	1	72	0	98	0	0.82	0	55.9	1.42503	7.9799
GSM1031660	1500	40.76	1	48.2	0	81	0	0.81	1	66.2	0.726322	8.27151
GSM1031659	1760	32.09	0	44.4	2	63	0	0.67	1	58.4	4.87111	21.3443
GSM1031658	1590	26.87	1	76	2	64	0	0.59	0	73.7	14.0428	25.5167
GSM1031657	1560	31.58	1	62	3	42	0	0.46	0	69.9	16.4386	50.2619
GSM1031656	1600	25.32	1	135	1	80	0	0.69	0	62	10.0245	18.4024
GSM1031655	1290	30.01	1	40	1	115	0	0.65	0	74.7	NA	NA
GSM1031654	1710	26.73	0	18.8	2	64	0	0.62	0	64	10.7203	29.7528
GSM1031653	1615	26.06	0	96.8	0	90	2	0.76	0	53.9	0.401558	0.475478
GSM1031652	1095	21.93	0	20	0	123	0	0.8	0	79.6	0.411735	11.0016
GSM103165	1658	21.87	0	64.5	0	115	0	0.79	0	68.4	1.85839	12.535
GSM1031650	1200	21.14	1	40	3	32	0	0.42	0	63.6	NA	NA
GSM1031649	1800	32.48	1	40.4	2	60	0	0.6	1	56.4	0.522144	8.92231
GSM1031648	1321	19.18	0	34.5	3	43	2	0.38	0	60.7	38.2897	59.5328
GSM1031647	1205	30.67	0	56.3	2	66	0	0.43	0	69.9	2.48365	NA
GSM1031646	2190	25.28	1	42	0	127	2	0.8	1	47	1.16811	14.6485
GSM1031645	1580	25.31	1	22.5	0	85	0	0.7	1	60.9	0.4431	5.81338
GSM1031644	2240	24.33	1	21.5	0	135	0	0.77	0	61.4	2.61274	9.99619
GSM1031643	1460	23.86	1	25.5	0	113	0	0.77	0	77.1	1.5044	8.41614
GSM1031642	1375	24.53	0	41.4	2	58	0	0.43	1	62.4	14.8882	52.2479
GSM103164	1310	30.03	0	22	0	92	0	0.71	0	66.4	7.85244	16.2783
GSM1031640	1303	25.31	1	75	1	83	0	0.67	0	67.3	2.93713	7.75215
GSM1031639	212	33.46	0	64	4	9	2	0.34	0	65.4	NA	NA
GSM1031638	970	19.98	0	38.4	2	69	1	0.58	1	49.4	5.09526	14.4233
GSM1031637	1750	35.02	0	16.7	0	89	0	0.81	1	51.4	0.0886364	0.395518
GSM1031636	2100	27.79	1	23.8	2	79	0	0.68	0	69.2	2.14922	9.71074
GSM1031635	1400	32.07	0	16.5	0	81	0	0.77	0	68.9	1.26639	10.4283
GSM1031634	1787	22.14	0	84	2	62	0	0.45	0	75.5	21.0042	50.8463
GSM1031633	1560	27.32	1	38	1	85	0	0.59	0	57.7	1.1811	9.36961
GSM1031632	0	21.68	0	70	4	18	0	0.24	0	57.3	23.0203	64.7798
GSM103163	1752	36.83	0	11	0	105	0	0.82	0	48.6	0.929728	2.64054
GSM1031630	1237	29.46	0	29.4	2	75	0	0.62	1	58.2	1.20979	21.5923
GSM1031629	1430	31.32	1	55	2	66	0	0.6	0	73.4	NA	NA
GSM1031628	1690	23.36	0	38.5	0	88	0	0.71	1	52.5	0.469038	6.24954
GSM1031627	1423	26.8	1	32	0	108	0	0.85	0	69.9	0.544681	8.62938
GSM1031626	1800	29.48	0	11	0	87	0	0.77	0	53	NA	NA
GSM1031625	1500	24.14	0	48.8	1	84	0	0.66	0	71.5	4.92016	30.3934
GSM1031624	1520	32.8	0	47.5	0	117	0	0.83	0	64	1.20747	5.59257
GSM1031623	1595	33.22	1	36.7	0	81	0	0.77	1	48.7	0.467616	5.68929
GSM1031622	2100	28.17	1	19.5	-1	70	0	0.78	0	64.8	0.263775	6.71099
GSM103162	2155	21.03	0	22	0	95	0	0.79	0	54.5	0.414945	3.08061
GSM1031620	1657	19.69	0	46.9	0	84	0	0.75	1	61.9	0.535603	4.0578
GSM1031619	1560	26.54	0	36.7	-1	75	0	0.73	1	56.7	0.099632	2.09425
GSM1031618	2485	24.1	0	45	0	89	0	0.77	0	56.2	0.455314	9.54353
GSM1031617	1640	27.96	1	44	0	98	2	0.7	0	59.8	NA	NA
GSM1031616	2080	23.31	0	12.8	0	97	0	0.74	0	57.2	0.670207	2.68791
GSM1031615	1955	27.02	1	60	0	100	1	0.81	0	57.8	4.90569	9.9683
GSM1031614	2100	23.39	0	23.9	1	80	0	0.68	1	67.8	0.226705	3.95366
GSM1031613	1600	25.16	1	25	0	114	0	0.76	0	65.2	0.322464	7.96997
GSM1031612	1680	26.27	0	16.4	-1	78	1	0.77	1	48.7	0.0977583	0.680464
GSM10316	1165	24.68	1	96.2	3	46	0	0.46	1	68.1	16.7414	48.0448
GSM1031610	890	28.18	1	56.3	3	39	0	0.24	0	60.2	19.2664	64.0679
GSM1031609	1490	24.1	1	35.6	-1	61	0	0.76	1	57.6	0.109741	8.30391
GSM1031608	420	36.09	1	74	2	66	1	0.66	0	52	3.76788	12.4339
GSM1031607	1032	15.57	1	69	4	29	0	0.33	0	66.3	NA	NA
GSM1031606	200	40.57	0	30.5	2	59	0	0.68	1	52.5	0.252877	4.70254
GSM1031605	1047	39.21	1	40	2	75	0	0.66	0	77	2.50719	21.3447
GSM1031604	985	18.66	1	12	4	25	0	0.25	0	71.7	19.7118	70.6538
GSM1031603	1335	35.32	1	106	2	72	0	0.64	0	77	2.74686	34.4623
GSM1031602	885	35.5	0	56.4	2	74	0	0.67	0	71.2	3.78237	13.7629
GSM103160	1230	21.42	0	27.5	3	46	0	0.44	0	75.1	30.6821	61.958
GSM1031600	2000	17.37	0	26.5	2	76	2	0.65	1	54.5	1.73655	14.3706
GSM1031599	1180	31.15	0	45	3	40	0	0.33	0	76.5	17.2392	55.5122
GSM1031598	1570	33.73	0	51.1	2	75	0	0.66	1	59.9	0.219367	7.55309
GSM1031597	2323	26.34	1	27	0	106	0	0.82	NA	60	0.642756	8.43404
GSM1031596	1515	29.08	0	36	-1	71	0	0.72	0	65.3	2.24143	27.4043
GSM1031595	1380	29.2	0	54.3	-1	75	0	0.79	1	50.2	0.0322462	NA
GSM1031594	1270	30.55	0	50	-1	67	0	0.74	0	69.7	0.206533	8.74406
GSM1031593	1220	44.87	1	43.5	2	50	0	0.49	0	58.5	4.25582	21.5466
GSM1031592	1103	29.67	0	35.3	3	42	0	0.44	0	68.4	18.9562	40.3396
GSM103159	2000	29.62	1	86.4	2	56	0	0.65	1	54.2	5.93111	31.8535
GSM1031590	971	23.36	1	39	4	20	2	0.35	0	60.5	25.6906	69.074
GSM1031589	742	25.64	1	114.3	4	29	1	0.32	1	58.7	8.51826	45.7929
GSM1031588	1152	26.72	0	38	4	22	0	0.29	0	62	16.5458	58.9834
GSM1031587	1610	20.31	1	52.5	3	46	0	0.35	0	77.7	25.434	65.8925
GSM1031586	905	17.47	0	45	4	26	0	0.29	0	62.1	34.2906	65.4102
GSM1031585	1030	30.72	0	48	4	24	0	0.23	0	54.1	32.1305	58.6963
GSM1031584	1500	34.52	1	145	0	88	0	0.72	0	78.5	2.23125	11.4664
GSM1031583	940	32.95	0	36	2	61	2	0.59	0	51.8	5.3201	22.6328
GSM1031582	1130	24.83	1	33	3	45	0	0.38	0	79.4	32.8289	57.1891
GSM103158	1340	26.31	1	124	3	44	0	0.39	0	75.2	NA	NA
GSM1031580	1375	26.17	1	48.5	0	89	0	0.76	1	48.3	0.762246	2.71143
GSM1031579	1605	27.78	1	12	2	75	0	0.5	0	52.1	5.39801	16.0263
GSM1031578	1400	35.29	1	64.5	2	67	1	0.65	0	62.7	1.58135	10.3269
GSM1031577	800	47.76	0	67.5	-1	70	2	0.77	0	58.9	0.968407	7.17103
GSM1031576	1000	21.88	1	67.5	3	34	1	0.41	0	73.4	45.063	70.1048
GSM1031575	360	38.56	1	78	4	25	0	0.33	0	72	17.1307	45.388
GSM1031574	970	37.5	0	34.1	0	86	0	0.8	1	49.1	0.231657	4.25385
GSM1031573	1670	24.28	1	38.8	3	32	2	0.31	0	65.7	11.6625	49.5014
GSM1031572	1737	22.83	0	51	0	98	0	0.79	0	71.5	0.917314	9.11688
GSM103157	1667	35.85	0	33	2	66	0	0.62	0	56.7	3.46247	16.0736
GSM1031570	1417	28.52	0	26	2	52	0	0.65	0	45	2.10546	19.1945
GSM1031569	1485	28.59	1	35	2	58	2	0.41	0	58.8	24.6265	67.5233
GSM1031568	1617	30.7	1	15	2	52	0	0.61	0	66.3	2.15975	11.9355
GSM1031567	1350	21.41	1	82	0	104	0	0.79	0	72.6	4.17798	21.6582
GSM1031566	935	23.23	0	50	3	32	0	0.37	0	70.5	26.8499	58.4832
GSM1031565	1190	36.55	1	94	4	26	0	0.38	0	65.9	2.10887	29.1561
GSM1031564	1351	26.12	0	33.4	0	84	1	0.7	1	48.4	0.615068	4.24508
GSM1031563	825	17.32	1	118.4	4	29	0	0.34	1	73.2	27.0944	65.3747
GSM1031562	1413	26.65	1	68	3	40	0	0.55	0	73.9	17.5086	56.2798
GSM103156	1130	29.11	0	47.5	3	39	1	0.42	0	71.3	11.2753	24.9955
GSM1031560	965	25.22	1	22	2	55	0	0.39	0	66.5	24.264	64.5543
GSM1031559	1088	37.33	1	55.5	3	36	0	0.46	0	65.4	NA	NA
GSM1031558	824	22.22	1	27	4	24	0	0.32	0	68.4	15.3613	52.0124
GSM1031557	2109	26.01	1	20	1	84	0	0.66	0	46.3	2.66028	33.5809
GSM1031556	538	17.92	0	46.8	2	60	2	0.69	0	55.8	NA	NA
GSM1031555	2100	24.4	0	50	0	101	0	0.71	0	60.6	1.08787	12.0421
GSM1031554	1460	26.87	0	34.6	0	96	2	0.76	1	50.6	NA	NA
GSM1031553	1641	30.82	1	39	0	94	1	0.78	0	61.2	1.58281	19.1088
GSM1031552	1010	23.62	0	41	3	32	0	0.43	0	75.8	NA	NA
GSM103155	1620	26.58	0	63	2	53	0	0.49	0	65.5	NA	NA
GSM1031550	1805	32.64	1	18	2	54	2	0.65	0	66.2	NA	NA
GSM1031549	1600	27.71	1	38	3	37	1	0.46	0	64.7	NA	NA