ArrayExpress Uploader07053controlweek 2controlweek 2controlweek 25 Gy radiation treatedweek 25 Gy radiation treatedweek 25 Gy radiation treatedweek 217.5 Gy radiation treatedweek 217.5 Gy radiation treatedweek 217.5 Gy radiation treatedweek 2controlweek 4controlweek 4controlweek 45 Gy radiation treatedweek 45 Gy radiation treatedweek 45 Gy radiation treatedweek 417.5 Gy radiation treatedweek 417.5 Gy radiation treatedweek 417.5 Gy radiation treatedweek 4controlweek 8controlweek 8controlweek 85 Gy radiation treatedweek 85 Gy radiation treatedweek 85 Gy radiation treatedweek 817.5 Gy radiation treatedweek 817.5 Gy radiation treatedweek 817.5 Gy radiation treatedweek 8controlweek 16controlweek 16controlweek 165 Gy radiation treatedweek 165 Gy radiation treatedweek 165 Gy radiation treatedweek 1617.5 Gy radiation treatedweek 1617.5 Gy radiation treatedweek 1617.5 Gy radiation treatedweek 16controlweek 30controlweek 30controlweek 305 Gy radiation treatedweek 305 Gy radiation treatedweek 305 Gy radiation treatedweek 3017.5 Gy radiation treatedweek 3017.5 Gy radiation treatedweek 3017.5 Gy radiation treatedweek 30arrayexpress_sid6Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of...24052614E-GEOD-41789/profile/8773/arrayexpressuploader245lungthoraxDec.12, 2014Falsesenescence-gene-signature-of-radiation-fibrosisE-GEOD-41789_A-AFFY-45Senescence gene signature of radiation fibrosisNov.12, 2014Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged animals. We demonstrate that NOX4 expression and superoxide elaboration is increased in irradiated lungs and pneumocytes in a dose dependent fashion. We used microarrays to detail the global programme of gene expression and report that irradiated lung tissue correlates with that observed in the lungs in aged animals. Female C57Bl/Ncr mice, aged 10 weeks were treated with/ without radiation to the thorax with a X-RAD 320 x-ray irradiator at a dose rate of 2.61 Gy/minute. An age-matched cohort of mice received no IR while additional cohorts received 5 Gy in a single dose, 17.5 Gy in a single dose. RNA was extracted and hybridization done on Affymetrix Mouse430_2 microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41789mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41789/samples/