ArrayExpress Uploader0mouseB6.129-Adrbk1tm1Mca/J backcrossed more than 20 generations onto C57BL/6JGRK2 heterozygous (GRK2+/-)B6.129-Adrbk1tm1Mca/J backcrossed more than 20 generations onto C57BL/6JGRK2 heterozygous (GRK2+/-)B6.129-Adrbk1tm1Mca/J backcrossed more than 20 generations onto C57BL/6JGRK2 heterozygous (GRK2+/-)C57BL/6Jwild typeC57BL/6Jwild typeC57BL/6Jwild type7049arrayexpress_sid6G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is...E-GEOD-41706/profile/8773/arrayexpressuploader26heartischemiaproteinDec.12, 2014Falseexpression-data-from-adult-9-month-old-hearts-fromE-GEOD-41706_A-AFFY-45Expression data from adult (9 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermatesNov.12, 2014G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genetic inhibition of GRK2 is cardioprotective in animal models of these pathologies. However, the mechanistic basis underlying these effects are not fully understood. We have used adult GRK2 hemizygous mice (GRK2+/-) as a model to assess the effects of a sustained systemic inhibition of GRK2 in heart tissue with age. We used microarrays to determine the global programme of gene expression underlying cardioprotection in GRK2 hemizygous mice. 9 month-old mice hearts were collected for RNA extraction and hybridization on Affymetrix microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41706http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41706/samples/