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In this study, we built on our previous molecular work to identify and...23319825E-GEOD-41613/profile/8773/arrayexpressuploader697carcinomacelloral squamous cell carcinomasquamoussquamous cellsquamous cell carcinomaDec.12, 2014Falsea-13-gene-signature-prognostic-of-hpv-negative-oscE-GEOD-41613_A-AFFY-44A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validationJul.12, 2014OSCC is associated with substantial mortality and morbidity. In this study, we built on our previous molecular work to identify and validate a prognostic 13-gene signature that showed a higher ability than tumor stage in predicting survival for patients with HPV-negative oral squamous cell carcinoma (OSCC). We previously reported 131 genes to be associated with survival in OSCC patients. In this study, we applied L1/L2-penalized Cox regression models to the Affymetrix array data from 97 HPV-negative OSCC patients on the 131 gene to identify a model for prediction of OSCC-specific survival. We then tested the model in an independent dataset and compared to tumor stage.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41613humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41613/samples/