ArrayExpress Uploader0humanaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermuscleplacebobeforemuscleplaceboaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermuscleplacebobeforemuscleplaceboaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolafteradipose tissueplacebobeforeadipose tissueplaceboaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleplacebobeforemuscleplaceboaftermuscleresveratrolbeforemuscleresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermuscleresveratrolbeforemuscleresveratrolafteradipose tissueresveratrolbeforeadipose tissueresveratrolaftermusclecalorie restrictivebeforemusclecalorie restrictiveafteradipose tissuecalorie restrictivebeforeadipose tissuecalorie restrictiveaftermuscleplacebobeforemuscleplaceboafteradipose tissueplacebobeforeadipose tissueplaceboaftermusclecalorie restrictivebeforemusclecalorie restrictive2602arrayexpress_sid4Resveratrol has been reported to improve metabolic function in metabolically-abnormal rodents and humans, but has not been studied in...E-GEOD-41168/profile/8773/arrayexpressuploader3140adipose tissuebodyglucoseinsulinlivermusclevastus lateralisDec.12, 2014Falseresveratrol-supplementation-does-not-improve-metabE-GEOD-41168_A-AFFY-44Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose toleranceJul.12, 2014Resveratrol has been reported to improve metabolic function in metabolically-abnormal rodents and humans, but has not been studied in non-obese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in non-obese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation was well-tolerated and increased plasma resveratrol concentration without adverse effects, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically-labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, Sirt1, Nampt, and Pgc-1α, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have metabolic effects in non-obese women. We compared gene expression profile in subcutaneous abdominal adipose tissue and skeletal muscle (vastus lateralis) biopsy samples obtained from non-obese people before and after 1) placebo (PLC), 2) resveratrol (RES), and 3) calorie restriction (CR) intervention.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41168http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41168/samples/