ArrayExpress Uploaderarrayexpress_sidhumanPDEF knockdownPDEF knockdowncontrolcontrol208604Microarray gene expression analysis was performed in MCF7 cells transduced with a non-specific shRNA or PDEF-targeting shRNA, and both...23764000E-GEOD-40985/profile/8773/arrayexpressuploader14cellhormoneDec.12, 2014Falsegene-expression-profiles-induced-by-shrna-mediatedE-GEOD-40985_A-AFFY-44Gene expression profiles induced by shRNA-mediated knockdown of PDEF in MCF7 mammary epithelial cell lineJul.11, 2014Microarray gene expression analysis was performed in MCF7 cells transduced with a non-specific shRNA or PDEF-targeting shRNA, and both subjected to hormone depletion for 48 hours. Analyses of differentially expressed genes combined with gene ontology revealed a downregulation of cell cycle related-genes and an upregulation of apoptosis-related genes in PDEF knockdown cells. These target genes constitute potential effectors of the pro-survival role of PDEF. Four samples were harvested after lentiviral infection with either non-specific shRNA control or PDEF-targetting shRNA. All samples were subjected to hormone depletion for 48 hours. Each condition was performed in duplicatehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40985http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40985/samples/