<?xml version="1.0" encoding="ASCII"?>
<biogps><data><item key="owner">ArrayExpress Uploader</item><item key="pop_total">0</item><item key="id">4582</item><item key="factors"><item><item key="GSM1006157"><item key="AVERAGE GIC50">28 nM</item><item key="CELL LINE">Pfeiffer</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006157"><item key="AVERAGE GIC50">28 nM</item><item key="CELL LINE">Pfeiffer</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006159"><item key="AVERAGE GIC50">28 nM</item><item key="CELL LINE">Pfeiffer</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006159"><item key="AVERAGE GIC50">28 nM</item><item key="CELL LINE">Pfeiffer</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100616"><item key="AVERAGE GIC50">134 nM nM</item><item key="CELL LINE">WSU-DLCL2</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006162"><item key="AVERAGE GIC50">134 nM</item><item key="CELL LINE">WSU-DLCL2</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006163"><item key="AVERAGE GIC50">134 nM</item><item key="CELL LINE">WSU-DLCL2</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006163"><item key="AVERAGE GIC50">134 nM</item><item key="CELL LINE">WSU-DLCL2</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006165"><item key="AVERAGE GIC50">232 nM</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006165"><item key="AVERAGE GIC50">232 nM</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006167"><item key="AVERAGE GIC50">232 nM</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006167"><item key="AVERAGE GIC50">232 nM</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006169"><item key="AVERAGE GIC50">448 nM</item><item key="CELL LINE">SU-DHL-10</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006169"><item key="AVERAGE GIC50">448 nM</item><item key="CELL LINE">SU-DHL-10</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100617"><item key="AVERAGE GIC50">448 nM</item><item key="CELL LINE">SU-DHL-10</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100617"><item key="AVERAGE GIC50">448 nM</item><item key="CELL LINE">SU-DHL-10</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006173"><item key="AVERAGE GIC50">516 nM</item><item key="CELL LINE">Ht</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006173"><item key="AVERAGE GIC50">516 nM</item><item key="CELL LINE">Ht</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006175"><item key="AVERAGE GIC50">516 nM</item><item key="CELL LINE">Ht</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006175"><item key="AVERAGE GIC50">516 nM</item><item key="CELL LINE">Ht</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006177"><item key="AVERAGE GIC50">582 nM</item><item key="CELL LINE">SU-DHL-6</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006177"><item key="AVERAGE GIC50">582 nM</item><item key="CELL LINE">SU-DHL-6</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006179"><item key="AVERAGE GIC50">582 nM</item><item key="CELL LINE">SU-DHL-6</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006179"><item key="AVERAGE GIC50">582 nM</item><item key="CELL LINE">SU-DHL-6</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100618"><item key="AVERAGE GIC50">861 nM</item><item key="CELL LINE">DB</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100618"><item key="AVERAGE GIC50">861 nM</item><item key="CELL LINE">DB</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006183"><item key="AVERAGE GIC50">861 nM</item><item key="CELL LINE">DB</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006183"><item key="AVERAGE GIC50">861 nM</item><item key="CELL LINE">DB</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006185"><item key="AVERAGE GIC50">1019 nM</item><item key="CELL LINE">OCI-LY-19</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006185"><item key="AVERAGE GIC50">1019 nM</item><item key="CELL LINE">OCI-LY-19</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006187"><item key="AVERAGE GIC50">1019 nM</item><item key="CELL LINE">OCI-LY-19</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006187"><item key="AVERAGE GIC50">1019 nM</item><item key="CELL LINE">OCI-LY-19</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006189"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">SU-DHL-4</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006189"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">SU-DHL-4</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100619"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">SU-DHL-4</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM100619"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">SU-DHL-4</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 mutant</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006193"><item key="AVERAGE GIC50">13786 nM</item><item key="CELL LINE">Toledo</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006193"><item key="AVERAGE GIC50">13786 nM</item><item key="CELL LINE">Toledo</item><item key="TREATMENT">DMSO (72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006195"><item key="AVERAGE GIC50">13786 nM</item><item key="CELL LINE">Toledo</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1006195"><item key="AVERAGE GIC50">13786 nM</item><item key="CELL LINE">Toledo</item><item key="TREATMENT">GSK126 (500nM; 72h)</item><item key="VARIATION">EZH2 wild type</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1012074"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">Non targetting Control (10days)</item><item key="VARIATION">not specified</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1012075"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">shEZH2 (10days)</item><item key="VARIATION">not specified</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1012074"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">Non targetting Control (10days)</item><item key="VARIATION">not specified</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1012075"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">KARPAS-422</item><item key="TREATMENT">shEZH2 (10days)</item><item key="VARIATION">not specified</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1012078"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">Pfeiffer</item><item key="TREATMENT">Non targetting Control (10days)</item><item key="VARIATION">not specified</item><item key="CHIP ANTIBODY">not specified</item></item></item><item><item key="GSM1012079"><item key="AVERAGE GIC50">not specified</item><item key="CELL LINE">Pfeiffer</item><item key="TREATMENT">shEZH2 (10days)</item><item key="VARIATION">not specified</item><item key="CHIP ANTIBODY">not specified</item></item></item></item><item key="ownerprofile_id">arrayexpress_sid</item><item key="platform">4</item><item key="summary_wrapped">This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant...</item><item key="pubmed_id">23051747</item><item key="geo_gse_id">E-GEOD-40972</item><item key="owner_profile">/profile/8773/arrayexpressuploader</item><item key="factor_count">5</item><item key="sample_count">46</item><item key="tags"><item>cell</item><item>histone</item></item><item key="lastmodified">Dec.12, 2014</item><item key="is_default">False</item><item key="geo_gds_id"/><item key="slug">ezh2-inhibition-as-a-therapeutic-strategy-for-lymp</item><item key="geo_id_plat">E-GEOD-40972_A-AFFY-44</item><item key="name">EZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations</item><item key="created">Sep.19, 2014</item><item key="summary">This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines GSE40971: Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor GSE41239: Gene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of  EZH2 Refer to individual Series</item><item key="source">http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40972</item><item key="species">human</item><item key="sample_source">http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40972/samples/</item></data></biogps>
