{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 4578, "factors": [{"GSM100410": {"INDIVIDUAL": "Subject 1", "TREATMENT": "saline"}}, {"GSM1004102": {"INDIVIDUAL": "Subject 1", "TREATMENT": "LPS"}}, {"GSM1004103": {"INDIVIDUAL": "Subject 2", "TREATMENT": "saline"}}, {"GSM1004104": {"INDIVIDUAL": "Subject 2", "TREATMENT": "LPS"}}, {"GSM1004105": {"INDIVIDUAL": "Subject 3", "TREATMENT": "saline"}}, {"GSM1004106": {"INDIVIDUAL": "Subject 3", "TREATMENT": "LPS"}}, {"GSM1004107": {"INDIVIDUAL": "Subject 4", "TREATMENT": "saline"}}, {"GSM1004108": {"INDIVIDUAL": "Subject 4", "TREATMENT": "LPS"}}, {"GSM1004109": {"INDIVIDUAL": "Subject 5", "TREATMENT": "saline"}}, {"GSM1004110": {"INDIVIDUAL": "Subject 5", "TREATMENT": "LPS"}}, {"GSM1004": {"INDIVIDUAL": "Subject 6", "TREATMENT": "saline"}}, {"GSM1004112": {"INDIVIDUAL": "Subject 6", "TREATMENT": "LPS"}}, {"GSM1004113": {"INDIVIDUAL": "Subject 7", "TREATMENT": "saline"}}, {"GSM1004114": {"INDIVIDUAL": "Subject 7", "TREATMENT": "LPS"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or...", "pubmed_id": 22952057, "geo_gse_id": "E-GEOD-40885", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 14, "tags": ["asthma", "chronic obstructive pulmonary disease", "disease", "genome", "lipopolysaccharide", "lung", "pneumonia"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "data-expression-in-alveolar-macrophages-induced-by", "geo_id_plat": "E-GEOD-40885_A-AFFY-44", "name": "Data expression in alveolar macrophages induced by lipopolysaccharide in humans", "created": "Sep.19, 2014", "summary": "Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes exposed to inhaled antigens.   Objectives: To obtain insight into which innate immune pathways become activated within human alveolar macrophages upon exposure to LPS in vivo. In seven healthy humans sterile saline was instilled into a lung segment by bronchoscope, followed by instillation of LPS into the contralateral lung. Six hours later a bilateral bronchoalveolar lavage was performed and whole-genome transcriptional profiling was done (Affymetrix HG-U133 Plus 2.0) on purified alveolar macrophages, comparing cells exposed to saline or LPS from the same individuals.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40885", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40885/samples/"}