6ArrayExpress Uploaderarrayexpress_sid7021expressednon-tumorApc (Min/+)/Spint1 (flox/flox)small intestinal mucosaexpressednon-tumorApc (Min/+)/Spint1 (flox/flox)small intestinal mucosaexpressedTumorApc (Min/+)/Spint1 (flox/flox)tumor of the small intestineexpressedTumorApc (Min/+)/Spint1 (flox/flox)tumor of the small intestineintestine-specific deletionnon-tumorApc (Min/+)/Spint1 (flox/flox)/Vil-Cresmall intestinal mucosaintestine-specific deletionnon-tumorApc (Min/+)/Spint1 (flox/flox)/Vil-Cresmall intestinal mucosaintestine-specific deletionTumorApc (Min/+)/Spint1 (flox/flox)/Vil-Cretumor of the small intestineintestine-specific deletionTumorApc (Min/+)/Spint1 (flox/flox)/Vil-Cretumor of the small intestine0http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40856To analyse roles of HAI-1/Spint1 in intestinal tumorigenesis, we examined the effect of intestine-specific deletion of Spint1 gene on...23447577/profile/8773/arrayexpressuploader48genomeintestinal mucosaintestinemucosasmall intestineDec.12, 2014FalseE-GEOD-40856_A-AFFY-45non-tumortumor-intestinal-tissue-of-control-or-intNon-tumor/tumor intestinal tissue of control or intestine-specific HAI-1 deficient Apc(Min/+) miceNov.12, 2014To analyse roles of HAI-1/Spint1 in intestinal tumorigenesis, we examined the effect of intestine-specific deletion of Spint1 gene on Apc(Min/+) mice. The loss of Hai-1/Spint1 significantly accelerated tumor formation in ApcMin/+ mice and shortened their survival periods. Mouse small intestine tumor tissue or background mucosa lacking macroscopically visible tumors were proceeded to RNA extraction and hybridization on microarrays (Affymetrix Mouse Genome 430 2.0 Array). Non-tumor or tumor intestinal mucosa tissues of Apc (Min/+)/Spint1 (flox/flox) mice and non-tumor or tumor intestinal mucosa tissues of Apc (Min/+)/Spint1 (flox/flox)/Vil-Cre mice were analysed. The experiment was repeated respectively.E-GEOD-40856mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40856/samples/