Dataset: Non-tumor/tumor intestinal tissue of control or intestine-specific HAI-1 deficient Apc(Min/+) mice

To analyse roles of HAI-1/Spint1 in intestinal tumorigenesis, we examined the effect of intestine-specific deletion of Spint1 gene on...

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To analyse roles of HAI-1/Spint1 in intestinal tumorigenesis, we examined the effect of intestine-specific deletion of Spint1 gene on Apc(Min/+) mice. The loss of Hai-1/Spint1 significantly accelerated tumor formation in ApcMin/+ mice and shortened their survival periods. Mouse small intestine tumor tissue or background mucosa lacking macroscopically visible tumors were proceeded to RNA extraction and hybridization on microarrays (Affymetrix Mouse Genome 430 2.0 Array). Non-tumor or tumor intestinal mucosa tissues of Apc (Min/+)/Spint1 (flox/flox) mice and non-tumor or tumor intestinal mucosa tissues of Apc (Min/+)/Spint1 (flox/flox)/Vil-Cre mice were analysed. The experiment was repeated respectively.

Species:: mouse
Samples:: 8
Source:: E-GEOD-40856
PubMed:: 23447577
Updated:: Dec.12, 2014
Registered:: Nov.12, 2014

Factors: (via ArrayExpress)

Sample	TISSUE TYPE	ORGANISM PART	HAI-1 EXPRESSION	GENOTYPE
GSM1003379	non-tumor	small intestinal mucosa	expressed	Apc (Min/+)/Spint1 (flox/flox)
GSM1003379	non-tumor	small intestinal mucosa	expressed	Apc (Min/+)/Spint1 (flox/flox)
GSM100338	Tumor	tumor of the small intestine	expressed	Apc (Min/+)/Spint1 (flox/flox)
GSM100338	Tumor	tumor of the small intestine	expressed	Apc (Min/+)/Spint1 (flox/flox)
GSM1003383	non-tumor	small intestinal mucosa	intestine-specific deletion	Apc (Min/+)/Spint1 (flox/flox)/Vil-Cre
GSM1003383	non-tumor	small intestinal mucosa	intestine-specific deletion	Apc (Min/+)/Spint1 (flox/flox)/Vil-Cre
GSM1003385	Tumor	tumor of the small intestine	intestine-specific deletion	Apc (Min/+)/Spint1 (flox/flox)/Vil-Cre
GSM1003385	Tumor	tumor of the small intestine	intestine-specific deletion	Apc (Min/+)/Spint1 (flox/flox)/Vil-Cre