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Home › Dataset Library › Expression data from fibroblasts cultured from normal and fibrotic human lung tissue

Dataset: Expression data from fibroblasts cultured from normal and fibrotic human lung tissue

Pulmonary fibrosis develops as a consequence of environmentally induced lung injury and/or an inherent disease susceptibility causing...

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Pulmonary fibrosis develops as a consequence of environmentally induced lung injury and/or an inherent disease susceptibility causing fibroblast activation, proliferation and extracellular matrix deposition. The study was undertaken to characterise global gene expression in pulmonary fibroblasts to better understand the mechanisms underlying the fibrotic fibroblast phenotype. Gene expression was evaluated in lung fibroblasts derived from ten controls (normal periphery of resected tumor), open lung biopsies from eight patients with interstitial lung disease associated with systemic sclerosis (fibrotic non specific interstitial pneumonia pattern on biopsy), and from three patients with usual interstitial pneumonia. Lung fibroblasts were grown to confluence in DMEM with 10% fetal calf serum. At confluence, lung fibroblasts were serum-deprived for 44 hours in the presence of fibroblast growth medium with the addition of 0.1% bovine serum albumin (Sigma).

Species:
human

Samples:
21

Source:
E-GEOD-40839

Updated:
Dec.12, 2014

Registered:
Jun.18, 2014


Factors: (via ArrayExpress)
Sample DISEASE STATUS
GSM1003078 Usual Interstitial Pneumonia
GSM1003078 Usual Interstitial Pneumonia
GSM1003078 Usual Interstitial Pneumonia
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003075 Scleroderma associated interstitial lung disease
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control
GSM1003067 control

Tags

  • disease
  • fibroblast
  • interstitial lung disease
  • lung
  • lung disease
  • pneumonia
  • pulmonary fibrosis
  • serum
  • systemic sclerosis

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