{"platform": 4, "owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM998569": {"CELL LINE": "Jurkat", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998569": {"CELL LINE": "Jurkat", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998567": {"CELL LINE": "Jurkat", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM998567": {"CELL LINE": "Jurkat", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM998565": {"CELL LINE": "DND41", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998565": {"CELL LINE": "DND41", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998563": {"CELL LINE": "DND41", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM998563": {"CELL LINE": "DND41", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM99856": {"CELL LINE": "CUTL1", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM99856": {"CELL LINE": "CUTL1", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998559": {"CELL LINE": "CUTL1", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM998559": {"CELL LINE": "CUTL1", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM998557": {"CELL LINE": "CEM", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998557": {"CELL LINE": "CEM", "TREATED WITH": "1 uM PD-0332991 for 15hrs"}}, {"GSM998555": {"CELL LINE": "CEM", "TREATED WITH": "DMSO for 15hrs"}}, {"GSM998555": {"CELL LINE": "CEM", "TREATED WITH": "DMSO for 15hrs"}}], "id": 2646, "pop_total": 0, "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40635", "summary_wrapped": "Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC....", "pubmed_id": 23079656, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 16, "tags": ["bone", "bone marrow", "cell", "genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-vehicle-or-pd-0332991-treated", "geo_id_plat": "E-GEOD-40635_A-AFFY-44", "name": "Expression data from vehicle or PD-0332991 treated human T-ALL lines", "created": "Jul.12, 2014", "summary": "Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro with PD-0332991 or vehicle control to determine genes affected by the drug. CEM, Jurkat, DND41, and CUTL-1 cell lines were treated with 1 uM PD-0332991 or DMSO for 15 hours prior to RNA extraction and hybridization to Human Genome U133 Plus 2.0 Affymetrix arrays.", "geo_gse_id": "E-GEOD-40635", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40635/samples/"}