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Home › Dataset Library › A cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer

Dataset: A cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer

Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and...

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Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and 15,500 deaths from ovarian cancer in the country (Siegel et al., 2012). While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of the tumor, understanding in the role of cancer associated fibroblasts (CAFs) in ovarian cancer progression is limited. We hypothesized that comparing the gene expression profiles of different components from laser capture microdissected ovarian tissue will allow us to identify an ovarian CAFs specific gene signature which accounts for the supportive role of CAFs in ovarian cancer progression. In this study, gene expression profiling was completed for 31 cancer stroma samples and 32 samples of epithelial component from high grade serous ovarian cancer patients. 8 microdissected normal ovarian stroma and 6 normal human ovarian surface epithelium (HOSE) samples were also included in the study. By comparing the expression data from cancer stroma against that from normal stroma, cancer cells and HOSE, we identified a set of differential expressed genes in ovarian CAFs which showed correlation with cancer patient survival. Further study on these genes can reveal their roles in ovarian cancer progression and pathogenesis. Ultimately, ovarian CAFs specified genes identified in this study may aid in the classification and enhancement of patient outcome. Transcriptome profiling analyses were performed on 31 laser microdissected cancer associated stroma samples, 32 epithelial tumor samples from high grade serous ovarian cancer patients, 8 microdissected normal ovarian stroma samples and 6 ovarian surface epthelium (HOSE) samples using the Affymetrix human genome U133 Plus 2.0 microarray.

Species:
human

Samples:
77

Source:
E-GEOD-40595

PubMed:
23824740

Updated:
Dec.12, 2014

Registered:
Sep.19, 2014


Factors: (via ArrayExpress)
Sample ORGANISM PART
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM99759 Microdissected normal ovarian stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997599 Microdissected ovarian cancer stroma
GSM997630 Microdissected ovarian surface epthelium
GSM997630 Microdissected ovarian surface epthelium
GSM997630 Microdissected ovarian surface epthelium
GSM997630 Microdissected ovarian surface epthelium
GSM997630 Microdissected ovarian surface epthelium
GSM997630 Microdissected ovarian surface epthelium
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component
GSM997636 Microdissected ovarian tumor epthelial component

Tags

  • cancer
  • genome
  • ovarian cancer
  • ovarian stroma
  • stroma
  • surface

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