ArrayExpress Uploader0human9807oculomotor neurons8507oculomotor neurons1207oculomotor neurons0507oculomotor neurons9807lumbar spinal motor neurons8507lumbar spinal motor neurons1207lumbar spinal motor neurons0507lumbar spinal motor neurons2525arrayexpress_sid4A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements. Pathological studies have confirmed...E-GEOD-40438/profile/8773/arrayexpressuploader28amyotrophic lateral sclerosisanteriorcranialdiseaseeyelaterallateral sclerosislcmmidbrainspinal cordDec.12, 2014Falsegene-expression-profiling-of-resistant-and-vulneraE-GEOD-40438_A-AFFY-44Gene expression profiling of resistant and vulnerable motor neuron subtypes in amyotrophic lateral sclerosisJul.12, 2014A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements. Pathological studies have confirmed that there is relative sparing of the cranial motor nuclei of the oculomotor, trochlear and abducens nerves, although pathological changes resembling those seen in anterior horn cells are present to a lesser degree. The aim of the present study is to combine LCM and microarray analysis to study the differences between motor neurons that are selectively resistant (oculomotor neurons) and those that are vulnerable (lumbar spinal motor neurons) to the disease process in amyotrophic lateral sclerosis. We used microarray analysis to determine the differences in gene expression between oculomotor and lumbar spinal motor neurons, isolated by laser capture microdissection from the midbrain and spinal cord of neurologically normal human controls.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40438http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40438/samples/