ArrayExpress Uploader0humanTNF (10ng/mL)+IL-17 (200ng/mL)48 hour cyotkine treatmentTNF (10ng/mL)+IL-17 (20ng/mL)48 hour cyotkine treatmentIL-17 (200ng/mL)48 hour cyotkine treatmentIL-17 (20ng/mL)48 hour cyotkine treatmentTNF (10ng/mL)48 hour cyotkine treatmentCtrl48 hour cyotkine treatmentTNF (10ng/mL)+IL-17 (200ng/mL)24 hour cytokine treatmentTNF (10ng/mL)+IL-17 (20ng/mL)24 hour cytokine treatmentIL-17 (200ng/mL)24 hour cytokine treatmentIL-17 (20ng/mL)24 hour cytokine treatmentTNF (10ng/mL)24 hour cytokine treatmentCtrl24 hour cytokine treatment2397arrayexpress_sid4In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines...E-GEOD-40413/profile/8773/arrayexpressuploader212linemelanocyteserumDec.12, 2014Falseil-17-and-tnf-synergistically-induce-growth-associE-GEOD-40413_A-AFFY-44IL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesisJul.12, 2014In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of melanogenesis pathway Comparison of one batch of primary human melanocyte line cultured in serum free media, treated with TNF and/or IL-17, for either 24 or 48 hours.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40413http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40413/samples/