{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6991, "factors": [{"GSM992480": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992480": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992480": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992480": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992480": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992485": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992485": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992485": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992485": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992485": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992490": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992490": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992490": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992490": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992490": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992490": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "vehicle control"}}, {"GSM992496": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992496": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992496": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992496": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992496": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992496": {"GENOTYPE": "WT", "ORGANISM PART": "hippocampus", "TREATMENT": "PDE10i"}}, {"GSM992502": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM992502": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM992502": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM992502": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM992502": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM992507": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992507": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992507": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992507": {"GENOTYPE": "PDE10A KO", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM9925": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM9925": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM9925": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM9925": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM9925": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "vehicle control"}}, {"GSM992516": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992516": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992516": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992516": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992516": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}, {"GSM992516": {"GENOTYPE": "WT", "ORGANISM PART": "striatum", "TREATMENT": "PDE10i"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases...", "pubmed_id": 20923867, "geo_gse_id": "E-GEOD-40377", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 42, "tags": ["disease", "histone", "huntington's disease", "nucleotide", "outside", "striatum"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "microarray-profiling-of-wt-or-pde10a-ko-mice-treat", "geo_id_plat": "E-GEOD-40377_A-AFFY-45", "name": "Microarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor", "created": "Nov.12, 2014", "summary": "Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of PDE10A activity would have significant effects on gene expression in the striatum. A comparison of the expression profile of PDE10A knockout (KO) mice and wild-type mice after chronic PDE10A inhibition revealed altered expression of 19 overlapping genes with few significant changes outside the striatum or after administration of a PDE10A inhibitor to KO animals. Chronic inhibition of PDE10A produced up-regulation of mRNAs encoding genes that included prodynorphin, synaptotagmin10, phosphodiesterase 1C, glutamate decarboxylase 1, and diacylglycerol O-acyltransferase and a down-regulation of mRNAs encoding choline acetyltransferase and Kv1.6, suggesting long-term suppression of the PDE10A enzyme is consistent with altered striatal excitability and potential utility as a antipsychotic therapy. In addition, up-regulation of mRNAs encoding histone 3 (H3) and down-regulation of histone deacetylase 4, follistatin, and claspin mRNAs suggests activation of molecular cascades capable of neuroprotection. We used lentiviral delivery of cAMP response element (CRE)-luciferase reporter constructs into the striatum and live animal imaging of 2-{4-[-pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline succinic acid (TP-10)-induced luciferase activity to further demonstrate PDE10 inhibition results in CRE-mediated transcription. Consistent with potential neuroprotective cascades, we also demonstrate phosphorylation of mitogen- and stress-activated kinase 1 and H3 in vivo after TP-10 treatment. The observed changes in signaling and gene expression are predicted to provide neuroprotective effects in models of Huntington's disease. n=4-6 per group.  WT mice used as a control for PDE10A KO mice, vehicle control for PDE10A inhibitor treatment.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40377", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40377/samples/"}