ArrayExpress Uploaderarrayexpress_sidmouseLsd1fl/flLsd1fl/flLsd1fl/fl EpoRCreLsd1fl/fl EpoRCre864408We discovered that mice lacking Lsd1 in the erythroid lineage die in utero of a lethal anemia around embryonic day E13.5. Lsd1 knockout...E-GEOD-40283/profile/8773/arrayexpressuploader14anemiagenomeDec.12, 2014Falsegene-expression-data-of-lsd1flfl-and-lsd1flfl-eporE-GEOD-40283_A-AFFY-36Gene expression data of Lsd1fl/fl and Lsd1fl/fl EpoRCre CD71_high / c-Kit_high pro-erythroblasts.Nov.24, 2014We discovered that mice lacking Lsd1 in the erythroid lineage die in utero of a lethal anemia around embryonic day E13.5. Lsd1 knockout embryos displayed an increase in CD71_high c-Kit_high pro-erythroblasts, followed by a drastic reduction of later maturation stages. To determine the genes altered by Lsd1-loss, CD71_high c-Kit_high pro-erythroblasts from Lsd1fl/fl and Lsd1fl/fl EpoRCre mice were FACS-purified to be analyzed by gene expression profiling. Primary CD71high c-Kithigh pro-erythroblasts were isolated by FACS-sorting from fetal livers of E13.5 Lsd1fl/fl and Lsd1fl/fl EpoRCre embryos. Total RNA from two biological replicates per genotype was extracted and used to hybridize to Affymetrix expression arrays using the Mouse Genome 430A array platform.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40283http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40283/samples/