{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM990647": {"GENOTYPE": "Lsd1fl/fl"}}, {"GSM990647": {"GENOTYPE": "Lsd1fl/fl"}}, {"GSM990649": {"GENOTYPE": "Lsd1fl/fl EpoRCre"}}, {"GSM990649": {"GENOTYPE": "Lsd1fl/fl EpoRCre"}}], "id": 8644, "pop_total": 0, "platform": 8, "summary_wrapped": "We discovered that mice lacking Lsd1 in the erythroid lineage die in utero of a lethal anemia around embryonic day E13.5. Lsd1 knockout...", "geo_gse_id": "E-GEOD-40283", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["anemia", "genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-data-of-lsd1flfl-and-lsd1flfl-epor", "geo_id_plat": "E-GEOD-40283_A-AFFY-36", "name": "Gene expression data of Lsd1fl/fl and Lsd1fl/fl EpoRCre CD71_high / c-Kit_high pro-erythroblasts.", "created": "Nov.24, 2014", "summary": "We discovered that mice lacking Lsd1 in the erythroid lineage die in utero of a lethal anemia around embryonic day E13.5. Lsd1 knockout embryos displayed an increase in CD71_high c-Kit_high pro-erythroblasts, followed by a drastic reduction of later maturation stages. To determine the genes altered by Lsd1-loss, CD71_high c-Kit_high pro-erythroblasts from Lsd1fl/fl and Lsd1fl/fl EpoRCre mice were FACS-purified to be analyzed by gene expression profiling. Primary CD71high c-Kithigh pro-erythroblasts were isolated by FACS-sorting from fetal livers of E13.5 Lsd1fl/fl and Lsd1fl/fl EpoRCre embryos. Total RNA from two biological replicates per genotype was extracted and used to hybridize to Affymetrix expression arrays using the Mouse Genome 430A array platform.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40283", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40283/samples/"}