ArrayExpress Uploaderarrayexpress_sidmousephenobarbitolwild-typephenobarbitolwild-typephenobarbitolmCAR knockoutphenobarbitolmCAR knockoutphenobarbitolhCAR transgenic in mCAR knockout backgroundphenobarbitolhCAR transgenic in mCAR knockout backgroundCITCO; 6-(4-chlorophenyl)imidazo[2-1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximewild-typeCITCO; 6-(4-chlorophenyl)imidazo[2-1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximewild-typeCITCO; 6-(4-chlorophenyl)imidazo[2-1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximemCAR knockoutCITCO; 6-(4-chlorophenyl)imidazo[2-1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximemCAR knockoutCITCO; 6-(4-chlorophenyl)imidazo[2-1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximehCAR transgenic in mCAR knockout backgroundCITCO; 6-(4-chlorophenyl)imidazo[2-1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximehCAR transgenic in mCAR knockout backgroundcorn oilwild-typecorn oilwild-typecorn oilmCAR knockoutcorn oilmCAR knockoutcorn oilhCAR transgenic in mCAR knockout backgroundcorn oilhCAR transgenic in mCAR knockout backgroundTCPOBOP; 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzenewild-typeTCPOBOP; 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzenewild-typeTCPOBOP; 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzenemCAR knockoutTCPOBOP; 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzenemCAR knockoutTCPOBOP; 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzenehCAR transgenic in mCAR knockout backgroundTCPOBOP; 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzenehCAR transgenic in mCAR knockout background828307This dataset is a four-ligand x three-genotype Affymetrix microarray analysis of the regulation of liver genes in the mouse by the...E-GEOD-40120/profile/8773/arrayexpressuploader224liverDec.12, 2014FalseE-GEOD-40120_A-AFFY-23microarray-analysis-of-genes-activated-by-mouse-caMicroarray analysis of genes activated by mouse CAR and human CAR in vivo.Nov.23, 2014This dataset is a four-ligand x three-genotype Affymetrix microarray analysis of the regulation of liver genes in the mouse by the constitutive androstane receptor (CAR). 24 female mice of mixed background (C57BL/6x129Sv) were divided into three groups: wild-type (contains only mouse CAR; mCAR), CAR.KO = knockout mice (mice ablated for mCAR gene; mCAR -/-), and CAR.AH= contains human CAR transgene under the control of the mouse albumin promoter in the mCAR -/- background. Each of the three groups underwent four different treatment regimens: CO = corn oil vehicle control, PB = phenobarbitol (100 mg/kg/day), an anti-convulsant agent which can translocate both mCAR and hCAR into the nucleus to turn on target gene expression, TC = TCPOBOP, a potent non-metabolized ligand of mCAR (3 mg/kg), CITCO = a hCAR specific ligand (30 mg/kg/day). Two mice were used per treatment group and each mouse RNA was used for one chip.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40120http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-40120/samples/