{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM979018": {"KNOCKDOWN": "H2ac"}}, {"GSM979018": {"KNOCKDOWN": "H2ac"}}, {"GSM979016": {"KNOCKDOWN": "scrambled siRNA"}}, {"GSM979016": {"KNOCKDOWN": "scrambled siRNA"}}], "id": 2348, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Estrogens(E2) are important steroid hormones that regulate differentiation, proliferation, and apoptosis in hormone-dependent breast...", "geo_gse_id": "E-GEOD-39786", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 4, "tags": ["breast", "breast cancer", "cancer", "cell", "hormone", "line"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-for-knockdown-of-h2ac-in-e2-treate", "geo_id_plat": "E-GEOD-39786_A-AFFY-44", "name": "Expression data for knockdown of H2ac in E2-treated MCF-7 cell lines", "created": "Jul.12, 2014", "summary": "Estrogens(E2) are important steroid hormones that regulate differentiation, proliferation, and apoptosis in hormone-dependent breast cancer.In order to detect the E2-dependent transcription program associated with the observed cell cycle response, we analyzed the effect of H2ac knockdown on MCF-7 gene expression using microarray. Interestingly, we noticed that 51% of the E2-upregulated genes are down-regulated by depletion of H2ac. The data also show that H2ac regulated E2-dependent genes through E2-induction signaling pathway. MCF-7 cell line was transfected with scrambled or H2ac siRNA in the absence or persence of E2.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39786", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39786/samples/"}