{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM971615": {"CELL TYPE": "B220+ cells sorted out from bone marrow after 4 weeks"}}, {"GSM971615": {"CELL TYPE": "B220+ cells sorted out from bone marrow after 4 weeks"}}, {"GSM971615": {"CELL TYPE": "B220+ cells sorted out from bone marrow after 4 weeks"}}, {"GSM971618": {"CELL TYPE": "PreB cell"}}, {"GSM971618": {"CELL TYPE": "PreB cell"}}, {"GSM971620": {"CELL TYPE": "ProB cell"}}, {"GSM971620": {"CELL TYPE": "ProB cell"}}, {"GSM971622": {"CELL TYPE": "CLP Ly6D- CLP cell"}}, {"GSM971622": {"CELL TYPE": "CLP Ly6D- CLP cell"}}, {"GSM971624": {"CELL TYPE": "CLP Ly6D+ CLP cell"}}, {"GSM971624": {"CELL TYPE": "CLP Ly6D+ CLP cell"}}, {"GSM971615": {"CELL TYPE": "B220+ cells sorted out from bone marrow after 4 weeks"}}, {"GSM971615": {"CELL TYPE": "B220+ cells sorted out from bone marrow after 4 weeks"}}, {"GSM971615": {"CELL TYPE": "B220+ cells sorted out from bone marrow after 4 weeks"}}], "id": 6959, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "we have investigated molecular and functional properties in  early B-lineage  cells from Pax-5 deficient animals crossed to a B-lineage...", "geo_gse_id": "E-GEOD-39554", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 14, "tags": ["bone", "bone marrow", "cell", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-early-b-cell-progenitors-incl", "geo_id_plat": "E-GEOD-39554_A-AFFY-45", "name": "Expression data from early B cell progenitors including CLP,ProB and PreB of Pax5 knockout and wild type C57Bl6 mice", "created": "Nov.12, 2014", "summary": "we have investigated molecular and functional properties in  early B-lineage  cells from Pax-5 deficient animals crossed to a B-lineage restricted reporter mouse. Gene expression analysis of ex  vivo isolated progenitor cells revealed that Pax-5 deficiency has a minor impact on Bcell specification.By  comparison  of  gene  expression  patterns  in  ex  vivo isolated Pax-5 and Ebf-1 deficient progenitors, it was possible to identify a set of B-cell restricted genes dependent of Ebf-1 but not Pax-5, supporting the idea that B-cell  specification  and  commitment  is  controlled  by  distinct  regulatory networks. wt \u03bb5 reporter+ and Pax5ko \u03bb5reporter+ fetal liver from d15 embryos isolated and transplanted into sublethaly irradiated mice. After 4 weeks B220+\u03bb5+ cells were sorted out from the bone marrow of the mice and subjected to microarray analyses", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39554", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39554/samples/"}