ArrayExpress Uploader0humanaggressive leukemiaT390non-targeting RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT210non-targeting RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT90non-targeting RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT60non-targeting RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT390non-targeting RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT210non-targeting RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT90non-targeting RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT60non-targeting RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT390DUSP1 RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT210DUSP1 RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT90DUSP1 RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT60DUSP1 RNAichronic lymphocytic leukemia B-cellSaggressive leukemiaT390DUSP1 RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT210DUSP1 RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT90DUSP1 RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT60DUSP1 RNAichronic lymphocytic leukemia B-cellusaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellSaggressive leukemiaT390nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT210nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT90nonechronic lymphocytic leukemia B-cellusaggressive leukemiaT60nonechronic lymphocytic leukemia B-cellusindolent leukemiaT390nonechronic lymphocytic leukemia B-cellSindolent leukemiaT210nonechronic lymphocytic leukemia B-cellSindolent leukemiaT90nonechronic lymphocytic leukemia B-cellSindolent leukemiaT60nonechronic lymphocytic leukemia B-cellSindolent leukemiaT390nonechronic lymphocytic leukemia B-cellusindolent leukemiaT210nonechronic lymphocytic leukemia B-cellusindolent leukemiaT90nonechronic lymphocytic leukemia B-cellusindolent leukemiaT60nonechronic lymphocytic leukemia B-cellusindolent leukemiaT390nonechronic lymphocytic leukemia B-cellSindolent leukemiaT210nonechronic lymphocytic leukemia B-cellSindolent leukemiaT90nonechronic lymphocytic leukemia B-cellSindolent leukemiaT60nonechronic lymphocytic leukemia B-cellSindolent leukemiaT390nonechronic lymphocytic leukemia B-cellusindolent leukemiaT210nonechronic lymphocytic leukemia B-cellusindolent leukemiaT90nonechronic lymphocytic leukemia B-cellusindolent leukemiaT60nonechronic lymphocytic leukemia B-cellusindolent leukemiaT390nonechronic lymphocytic leukemia B-cellSindolent leukemiaT210nonechronic lymphocytic leukemia B-cellSindolent leukemiaT90nonechronic lymphocytic leukemia B-cellSindolent leukemiaT60nonechronic lymphocytic leukemia B-cellSindolent leukemiaT390nonechronic lymphocytic leukemia B-cellusindolent leukemiaT210nonechronic lymphocytic leukemia B-cellusindolent leukemiaT90nonechronic lymphocytic leukemia B-cellusindolent leukemiaT60nonechronic lymphocytic leukemia B-cellusindolent leukemiaT390nonechronic lymphocytic leukemia B-cellSindolent leukemiaT210nonechronic lymphocytic leukemia B-cellSindolent leukemiaT90nonechronic lymphocytic leukemia B-cellSindolent leukemiaT60nonechronic lymphocytic leukemia B-cellSindolent leukemiaT390nonechronic lymphocytic leukemia B-cellusindolent leukemiaT210nonechronic lymphocytic leukemia B-cellusindolent leukemiaT90nonechronic lymphocytic leukemia B-cellusindolent leukemiaT60nonechronic lymphocytic leukemia B-cellusindolent leukemiaT390nonechronic lymphocytic leukemia B-cellSindolent leukemiaT210nonechronic lymphocytic leukemia B-cellSindolent leukemiaT90nonechronic lymphocytic leukemia B-cellSindolent leukemiaT60nonechronic lymphocytic leukemia B-cellSindolent leukemiaT390nonechronic lymphocytic leukemia B-cellusindolent leukemiaT210nonechronic lymphocytic leukemia B-cellusindolent leukemiaT90nonechronic lymphocytic leukemia B-cellusindolent leukemiaT60nonechronic lymphocytic leukemia B-cellusindolent leukemiaT390nonechronic lymphocytic leukemia B-cellSindolent leukemiaT210nonechronic lymphocytic leukemia B-cellSindolent leukemiaT90nonechronic lymphocytic leukemia B-cellSindolent leukemiaT60nonechronic lymphocytic leukemia B-cellSindolent leukemiaT390nonechronic lymphocytic leukemia B-cellusindolent leukemiaT210nonechronic lymphocytic leukemia B-cellusindolent leukemiaT90nonechronic lymphocytic leukemia B-cellusindolent leukemiaT60nonechronic lymphocytic leukemia B-cellushealthy controlT390noneHealthy B-cellShealthy controlT210noneHealthy B-cellShealthy controlT90noneHealthy B-cellShealthy controlT60noneHealthy B-cellShealthy controlT390noneHealthy B-cellushealthy controlT210noneHealthy B-cellushealthy controlT90noneHealthy B-cellushealthy controlT60noneHealthy B-cellushealthy controlT390noneHealthy B-cellShealthy controlT210noneHealthy B-cellShealthy controlT90noneHealthy B-cellShealthy controlT60noneHealthy B-cellShealthy controlT390noneHealthy B-cellushealthy controlT210noneHealthy B-cellushealthy controlT90noneHealthy B-cellushealthy controlT60noneHealthy B-cellushealthy controlT390noneHealthy B-cellShealthy controlT210noneHealthy B-cellShealthy controlT90noneHealthy B-cellShealthy controlT60noneHealthy B-cellShealthy controlT390noneHealthy B-cellushealthy controlT210noneHealthy B-cellushealthy controlT90noneHealthy B-cellushealthy controlT60noneHealthy B-cellushealthy controlT390noneHealthy B-cellShealthy controlT210noneHealthy B-cellShealthy controlT90noneHealthy B-cellShealthy controlT60noneHealthy B-cellShealthy controlT390noneHealthy B-cellushealthy controlT210noneHealthy B-cellushealthy controlT90noneHealthy B-cellushealthy controlT60noneHealthy B-cellushealthy controlT390noneHealthy B-cellShealthy controlT210noneHealthy B-cellShealthy controlT90noneHealthy B-cellShealthy controlT60noneHealthy B-cellShealthy controlT390noneHealthy B-cellushealthy controlT210noneHealthy B-cellushealthy controlT90noneHealthy B-cellushealthy controlT60noneHealthy B-cellushealthy controlT390noneHealthy B-cellShealthy controlT210noneHealthy B-cellShealthy controlT90noneHealthy B-cellShealthy controlT60noneHealthy B-cellShealthy controlT390noneHealthy B-cellushealthy controlT210noneHealthy B-cellushealthy controlT90noneHealthy B-cellushealthy controlT60noneHealthy B-cellus2591arrayexpress_sid4Three different cell populations (6 healthy B-lymphocytes, 6 leukemic CLL B-lymphocyte of indolent form and 5 leukemic CLL B-lymphocyte...23267079/profile/8773/arrayexpressuploader5152cellclllymphocyteDec.12, 2014FalseE-GEOD-39411_A-AFFY-44expression-data-from-healthy-and-malignant-chronichttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39411Expression data from healthy and malignant (chronic lymphocytic leukemia, CLL) human B-lymphocytes after B-cell receptor stimulationJul.12, 2014Three different cell populations (6 healthy B-lymphocytes, 6 leukemic CLL B-lymphocyte of indolent form and 5 leukemic CLL B-lymphocyte of aggressive form) were stimulated in vitro with an anti-IgM antibody, activating the B-cell receptor (BCR). We analyzed the gene expression at 4 time points (60, 90, 210 and 390 minutes). Each gene expression measurement is performed both in stimulated cells and in control unstimulated cells. For one aggressive CLL case, we silenced expression of DUSP1 by transfecting DUSP1-specific RNAi and, as a control, transfected cells with a non-targeting RNAi. We then stimulated the BCR of these cells and analyzed the gene expression at the same time points in stimulated cells and in control unstimulated cells. B-cells were negatively selected from healthy donors and previously untreated CLL patients. BCR stimulated and unstimulated control B-cells were treated at four time points after stimulation for total RNA extraction and hybridization on Affymetrix microarrays.E-GEOD-39411http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39411/samples/