{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM967426": {"AGE": "5 months", "GENOTYPE": "wild-type"}}, {"GSM967427": {"AGE": "5 months", "GENOTYPE": "WHV/c-myc transgenic"}}, {"GSM967428": {"AGE": "11 months", "GENOTYPE": "wild-type"}}, {"GSM967429": {"AGE": "11 months", "GENOTYPE": "WHV/c-myc transgenic"}}], "id": 6950, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "The WHV/c-myc transgenic mouse is an animal model of hepatocarcinogenesis that can exquisitely mimic the cancer staging in human...", "geo_gse_id": "E-GEOD-39401", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 4, "tags": ["cancer", "carcinoma", "genome", "hepatitis", "hepatocellular carcinoma", "hepatocyte", "liver", "point"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-of-whvc-myc-transgenic-mice-at-pre", "geo_id_plat": "E-GEOD-39401_A-AFFY-45", "name": "Expression data of WHV/c-myc transgenic mice at preneoplastic and neoplastic stages", "created": "Nov.12, 2014", "summary": "The WHV/c-myc transgenic mouse is an animal model of hepatocarcinogenesis that can exquisitely mimic the cancer staging in human Hepatocellular carcinoma (HCC), in which the c-myc oncogene is activated by adjacent woodchuck hepatitis virus (WHV) DNA sequences. Compared to other models of c-myc transgenic mice, WHV/c-myc mice stably develop HCC with a relatively short latent period of 8 to 12 months, with a high (near 100%) tumor incidence. The aim of this study was to discover new HCC biomarkers and analyze expression patterns of selected candidate biomarkers prior to liver tumor onset by employing WHV/c-myc transgenic mice. Using Affymetrix Mouse Genome 430 2.0 Expression Arrays, we studied hepatic gene expression profiles of WHV/c-myc transgenic mice at 5 months and 11 months, age-matched wild-type C57/BL6 mice were used as controls. At 5 months, the livers of transgenic mice exhibited mild to moderate hepatocyte dysplasia, this time point represents the preneoplastic stage. At 11 months, the tumors were visualized in WHV/c-myc transgenic mice and consisted mainly of well-differentiated, trabecular-type HCCs, and this time point was considered as neoplastic stage.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39401", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-39401/samples/"}